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• W4210958761 endingPage "588" @default.
• W4210958761 startingPage "574" @default.
• W4210958761 abstract "Phenytoin was the first effective antiepileptic drug (AED) developed from systematic scientifically based molecule screening. It prevents or reduces the severity of induced seizures in various animal models of generalized convulsive epileptic seizures. The antiepileptic effect of phenytoin at therapeutically relevant concentrations appears to depend on its capacity to bind to, and prolong the inactivation state, particularly the fast inactivated state, of mammalian voltage-dependent sodium ion channels in neuronal cell membranes. In recent years, little has been added to the knowledge of the pharmacokinetics of phenytoin. This chapter provides references cited mainly for more recently established facts. Numerous interactions between phenytoin and endogenous substances and co-administered drugs have been reported. Within limits, increasing phenytoin doses and the consequent increases in serum phenytoin concentrations correlate with increasing degrees of seizure control in types of epilepsy responsive to the drug. Intravenous phenytoin often provides effective treatment for convulsive status epilepticus." @default.
• W4210958761 created "2022-02-13" @default.
• W4210958761 creator A5052099914 @default.
• W4210958761 date "2015-10-02" @default.
• W4210958761 modified "2023-10-18" @default.
• W4210958761 title "Phenytoin" @default.
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