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- W4210959709 abstract "Ion channels are essential for myriad cellular functions and their regulation is a critical pharmacological strategy for many diseases. However, traditional small-molecule and peptide-based therapeutics that target these channels are often inadequate, as their systemic distribution can lead to modulation of their target protein in off-target tissues. Gene therapy is an alluring alternative, with the potential to restrict transgene expression to a defined tissue. Here, we create a toolset to modulate the ubiquitin status of a target protein with divalent nanobodies (‘Divas’) that recruit the HECT domain of Nedd4L to a protein of interest." @default.
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- W4210959709 date "2022-02-01" @default.
- W4210959709 modified "2023-09-26" @default.
- W4210959709 title "Bidirectional modulation of ion channels with divalent nanobodies" @default.
- W4210959709 doi "https://doi.org/10.1016/j.bpj.2021.11.819" @default.
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