FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210962011> ?p ?o ?g. }

• W4210962011 endingPage "15" @default.
• W4210962011 startingPage "1" @default.
• W4210962011 abstract "Overview Endometrial carcinoma is the most frequent gynecologic cancer in the United States with over 50,000 new cases diagnosed per year. Over 80% have Type I cancers with the classic estrogen‐dependent endometrioid histology and a favorable prognosis. Type II cancers have a different molecular profile associated with more virulent disease and diminished survival and include uterine serous papillary carcinomas (UPSC) and clear cell carcinomas. The Cancer Genome Atlas (TCGA) has recently defined four molecular subtypes of endometrial cancer based on somatic mutations, copy number alterations, and microsatellite instability status. Over 75% of patients are present with irregular or postmenopausal bleeding. Surgical staging includes a total hysterectomy, bilateral salpingo‐oophorectomy, and pelvic and para‐aortic lymph node sampling, which can be performed via a laparotomy, laparoscopy, or robotic surgery. Surgery, where possible, constitutes the definitive primary treatment for most patients with endometrial carcinoma. Primary radiation therapy and primary hormonal therapy are alternatives for inoperable patients. Adjuvant therapy for Stage I disease is determined by age, depth of myometrial invasion, lymphovascular space invasion, and tumor grade. For patients with advanced and recurrent disease, radiation therapy, chemotherapy, and hormonal therapy are utilized. Paclitaxel (T), carboplatin (C), cisplatin (P), and doxorubicin (A) are the most active single agents with TC and TAP being the most effective combination of chemotherapy regimens. Hormonal therapy includes oral progestins, the progesterone‐containing intrauterine device, tamoxifen, gonadotropin‐releasing hormone analogs, and aromatase inhibitors. Emerging biologic agents with activity include bevacizumab and mTOR inhibitors. Tumor molecular profiling, minimal invasive surgery, sentinel lymph node assessment, and integration of novel biologic therapies will likely play a greater role in the future." @default.
• W4210962011 created "2022-02-13" @default.
• W4210962011 creator A5052817109 @default.
• W4210962011 creator A5071811135 @default.
• W4210962011 creator A5078692182 @default.
• W4210962011 date "2017-02-26" @default.
• W4210962011 modified "2023-09-25" @default.
• W4210962011 title "Endometrial Cancer" @default.
• W4210962011 cites W1511782158 @default.
• W4210962011 cites W1513519854 @default.
• W4210962011 cites W1526539352 @default.
• W4210962011 cites W1832839964 @default.
• W4210962011 cites W1920126165 @default.
• W4210962011 cites W1933506009 @default.
• W4210962011 cites W1949779401 @default.
• W4210962011 cites W1958951208 @default.
• W4210962011 cites W1963769544 @default.
• W4210962011 cites W1964577828 @default.
• W4210962011 cites W1964619316 @default.
• W4210962011 cites W1964937608 @default.
• W4210962011 cites W1966158740 @default.
• W4210962011 cites W1967632206 @default.
• W4210962011 cites W1968400287 @default.
• W4210962011 cites W1970950714 @default.
• W4210962011 cites W1971890783 @default.
• W4210962011 cites W1975704460 @default.
• W4210962011 cites W1978251501 @default.
• W4210962011 cites W1978329242 @default.
• W4210962011 cites W1980551630 @default.
• W4210962011 cites W1980601031 @default.
• W4210962011 cites W1981476886 @default.
• W4210962011 cites W1981534925 @default.
• W4210962011 cites W1982192876 @default.
• W4210962011 cites W1983158399 @default.
• W4210962011 cites W1987405808 @default.
• W4210962011 cites W1988275568 @default.
• W4210962011 cites W1988855646 @default.
• W4210962011 cites W1988942529 @default.
• W4210962011 cites W1989490517 @default.
• W4210962011 cites W1992523140 @default.
• W4210962011 cites W1993925306 @default.
• W4210962011 cites W1996824037 @default.
• W4210962011 cites W1997333866 @default.
• W4210962011 cites W1997436128 @default.
• W4210962011 cites W1997486108 @default.
• W4210962011 cites W1999089268 @default.
• W4210962011 cites W1999143226 @default.
• W4210962011 cites W1999544439 @default.
• W4210962011 cites W2002006344 @default.
• W4210962011 cites W2002372441 @default.
• W4210962011 cites W2002521386 @default.
• W4210962011 cites W2002831173 @default.
• W4210962011 cites W2003261631 @default.
• W4210962011 cites W2006965792 @default.
• W4210962011 cites W2008738124 @default.
• W4210962011 cites W2011444479 @default.
• W4210962011 cites W2011485919 @default.
• W4210962011 cites W2011610784 @default.
• W4210962011 cites W2011978272 @default.
• W4210962011 cites W2014135632 @default.
• W4210962011 cites W2016294917 @default.
• W4210962011 cites W2016558284 @default.
• W4210962011 cites W2016723810 @default.
• W4210962011 cites W2017903755 @default.
• W4210962011 cites W2018337400 @default.
• W4210962011 cites W2019833810 @default.
• W4210962011 cites W2020032026 @default.
• W4210962011 cites W2025372445 @default.
• W4210962011 cites W2026366091 @default.
• W4210962011 cites W2027851127 @default.
• W4210962011 cites W2027862992 @default.
• W4210962011 cites W2028878627 @default.
• W4210962011 cites W2029525433 @default.
• W4210962011 cites W2030082597 @default.
• W4210962011 cites W2030619756 @default.
• W4210962011 cites W2031222466 @default.
• W4210962011 cites W2033082552 @default.
• W4210962011 cites W2033141703 @default.
• W4210962011 cites W2035971251 @default.
• W4210962011 cites W2036041581 @default.
• W4210962011 cites W2036844834 @default.
• W4210962011 cites W2036913860 @default.
• W4210962011 cites W2039155094 @default.
• W4210962011 cites W2039394685 @default.
• W4210962011 cites W2039900153 @default.
• W4210962011 cites W2041094935 @default.
• W4210962011 cites W2041440766 @default.
• W4210962011 cites W2041901579 @default.
• W4210962011 cites W2042876799 @default.
• W4210962011 cites W2043012914 @default.
• W4210962011 cites W2044869180 @default.
• W4210962011 cites W2046089575 @default.
• W4210962011 cites W2046456934 @default.
• W4210962011 cites W2046598680 @default.
• W4210962011 cites W2047111383 @default.
• W4210962011 cites W2049941029 @default.
• W4210962011 cites W2050596640 @default.
• W4210962011 cites W2051954544 @default.

• next