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• W4210966908 abstract "There is an urgent need for novel drug leads, especially for microbial infections due to continuing emergence of drug resistance. Natural products are the backbone of modern medicine and the lichens have an important role to play in the discovery of novel drugs. Indonesia is gifted with a diverse array of lichens, which remain underexplored for medicinal applications. In this study, we have collected a lichen, Candelaria fibrosa, and conducted phytochemical and bioactivity studies. Using high performance liquid chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy, we have isolated and characterised two depside compounds, atraric acid (7) and methyl 3-hydroxy orsellinate (8). These two depsides were reported from this lichen species for the first time. The evaluation of the crude methanol extract against Gram-positive bacteria, Staphylococcus aureus, indicated insignificant activity. However, the isolated compounds have been previously reported to possess low antimicrobial activity against common pathogenic bacteria (Staphylococcus aureus, Bacillus cereus and Pseudomonas aeruginosa) but to show significant anti-legionellosis." @default.
• W4210966908 created "2022-02-13" @default.
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• W4210966908 date "2022-01-02" @default.
• W4210966908 modified "2023-10-17" @default.
• W4210966908 title "Isolation of Antibacterial Depside Constituents from Indonesian Folious Lichen, <i>Candelaria fibrosa</i>" @default.
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• W4210966908 doi "https://doi.org/10.1080/22311866.2021.2021986" @default.
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