Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210972389> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W4210972389 abstract "BACKGROUND: Animal models suggest that immunomodulatory properties of macrolide antibiotics have therapeutic value for patients with acute lung injury (ALI). We investigated the association between receipt of macrolide antibiotics and clinical outcomes in patients with ALI.METHODS: Secondary analysis of multicenter, randomized controlled trial data from the Acute Respiratory Distress Syndrome Network Lisofylline and Respiratory Management of Acute Lung Injury Trial, which collected detailed data regarding antibiotic use among participants with ALI.RESULTS: Forty-seven of 235 participants (20%) received a macrolide antibiotic within 24 h of trial enrollment. Among patients who received a macrolide, erythromycin was the most common (57%), followed by azithromycin (40%). The median duration of macrolide use after study enrollment was 4 days (interquartile range, 2-8 days). Eleven of the 47 (23%) patients who received macrolides died, compared with 67 of the 188 (36%) who did not receive a macrolide (P = .11). Participants administered macrolides were more likely to have pneumonia as an ALI risk factor, were less likely to have nonpulmonary sepsis or to be randomized to low tidal volume ventilation, and had a shorter length of stay prior to trial enrollment. After adjusting for potentially confounding covariates, use of macrolide was associated with lower 180-day mortality (hazard ratio [HR], 0.46; 95% CI, 0.23-0.92; P = .028) and shorter time to successful discontinuation of mechanical ventilation (HR, 1.93; 95% CI, 1.18-3.17; P = .009). In contrast, fluoroquinolone (n = 90) and cephalosporin antibiotics (n = 93) were not associated with improved outcomes.CONCLUSIONS: Receipt of macrolide antibiotics was associated with improved outcomes in patients with ALI. PMID: 22116799 Funding information This work was supported by: NCI NIH HHS, United States Grant ID: K07 CA138772" @default.
- W4210972389 created "2022-02-13" @default.
- W4210972389 creator A5031081653 @default.
- W4210972389 date "2011-12-01" @default.
- W4210972389 modified "2023-10-16" @default.
- W4210972389 title "Faculty Opinions recommendation of Macrolide antibiotics and survival in patients with acute lung injury." @default.
- W4210972389 doi "https://doi.org/10.3410/f.13383956.14751054" @default.
- W4210972389 hasPublicationYear "2011" @default.
- W4210972389 type Work @default.
- W4210972389 citedByCount "0" @default.
- W4210972389 crossrefType "dataset" @default.
- W4210972389 hasAuthorship W4210972389A5031081653 @default.
- W4210972389 hasBestOaLocation W42109723891 @default.
- W4210972389 hasConcept C119060515 @default.
- W4210972389 hasConcept C126322002 @default.
- W4210972389 hasConcept C168563851 @default.
- W4210972389 hasConcept C207103383 @default.
- W4210972389 hasConcept C2777914695 @default.
- W4210972389 hasConcept C2778155338 @default.
- W4210972389 hasConcept C2778907293 @default.
- W4210972389 hasConcept C2780206985 @default.
- W4210972389 hasConcept C44249647 @default.
- W4210972389 hasConcept C501593827 @default.
- W4210972389 hasConcept C71924100 @default.
- W4210972389 hasConcept C86803240 @default.
- W4210972389 hasConcept C89423630 @default.
- W4210972389 hasConceptScore W4210972389C119060515 @default.
- W4210972389 hasConceptScore W4210972389C126322002 @default.
- W4210972389 hasConceptScore W4210972389C168563851 @default.
- W4210972389 hasConceptScore W4210972389C207103383 @default.
- W4210972389 hasConceptScore W4210972389C2777914695 @default.
- W4210972389 hasConceptScore W4210972389C2778155338 @default.
- W4210972389 hasConceptScore W4210972389C2778907293 @default.
- W4210972389 hasConceptScore W4210972389C2780206985 @default.
- W4210972389 hasConceptScore W4210972389C44249647 @default.
- W4210972389 hasConceptScore W4210972389C501593827 @default.
- W4210972389 hasConceptScore W4210972389C71924100 @default.
- W4210972389 hasConceptScore W4210972389C86803240 @default.
- W4210972389 hasConceptScore W4210972389C89423630 @default.
- W4210972389 hasLocation W42109723891 @default.
- W4210972389 hasOpenAccess W4210972389 @default.
- W4210972389 hasPrimaryLocation W42109723891 @default.
- W4210972389 hasRelatedWork W2001895976 @default.
- W4210972389 hasRelatedWork W2048271982 @default.
- W4210972389 hasRelatedWork W2071110455 @default.
- W4210972389 hasRelatedWork W2097744981 @default.
- W4210972389 hasRelatedWork W2377200934 @default.
- W4210972389 hasRelatedWork W2733532143 @default.
- W4210972389 hasRelatedWork W3007905284 @default.
- W4210972389 hasRelatedWork W3089113296 @default.
- W4210972389 hasRelatedWork W4238669509 @default.
- W4210972389 hasRelatedWork W4301904442 @default.
- W4210972389 isParatext "false" @default.
- W4210972389 isRetracted "false" @default.
- W4210972389 workType "dataset" @default.