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- W4210972925 abstract "Pemphigus is a group of IgG-mediated autoimmune diseases of stratified squamous epithelia, such as the skin and oral mucosa, in which acantholysis (the loss of cell adhesion) causes blisters and erosions. Pemphigus has three major subtypes: pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. IgG autoantibodies are characteristically raised against desmoglein 1 and desmoglein 3, which are cell–cell adhesion molecules found in desmosomes. The sites of blister formation can be physiologically explained by the anti-desmoglein autoantibody profile and tissue-specific expression pattern of desmoglein isoforms. The pathophysiological roles of T cells and B cells have been characterized in mouse models of pemphigus and patients, revealing insights into the mechanisms of autoimmunity. Diagnosis is based on clinical manifestations and confirmed with histological and immunochemical testing. The current first-line treatment is systemic corticosteroids and adjuvant therapies, including immunosuppressive agents, intravenous immunoglobulin and plasmapheresis. Rituximab, a monoclonal antibody against CD20+ B cells, is a promising therapeutic option that may soon become first-line therapy. Pemphigus is one of the best-characterized human autoimmune diseases and provides an ideal paradigm for both basic and clinical research, especially towards the development of antigen-specific immune suppression treatments for autoimmune diseases. Pemphigus is an autoimmune disorder characterized by blisters in the oral mucosa and epidermis. Acantholysis (loss of cell adhesion, which results in blisters) is caused by the presence of autoantibodies that target desmosomal proteins, in particular, desmoglein 1 and desmoglein 3." @default.
- W4210972925 created "2022-02-13" @default.
- W4210972925 creator A5003409611 @default.
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- W4210972925 creator A5067952566 @default.
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- W4210972925 creator A5090549024 @default.
- W4210972925 date "2017-05-11" @default.
- W4210972925 modified "2023-10-13" @default.
- W4210972925 title "Pemphigus" @default.
- W4210972925 cites W1032599614 @default.
- W4210972925 cites W1493998640 @default.
- W4210972925 cites W1498853059 @default.
- W4210972925 cites W1511912893 @default.
- W4210972925 cites W1538904555 @default.
- W4210972925 cites W1540594090 @default.
- W4210972925 cites W1542487405 @default.
- W4210972925 cites W1545566206 @default.
- W4210972925 cites W1550079537 @default.
- W4210972925 cites W1568431196 @default.
- W4210972925 cites W1586534080 @default.
- W4210972925 cites W1586900544 @default.
- W4210972925 cites W1588270000 @default.
- W4210972925 cites W1596871903 @default.
- W4210972925 cites W1601441880 @default.
- W4210972925 cites W1602264889 @default.
- W4210972925 cites W1622654657 @default.
- W4210972925 cites W170794068 @default.
- W4210972925 cites W1781160907 @default.
- W4210972925 cites W1859877305 @default.
- W4210972925 cites W1892976117 @default.
- W4210972925 cites W1897890915 @default.
- W4210972925 cites W1899066263 @default.
- W4210972925 cites W1905845038 @default.
- W4210972925 cites W1913275243 @default.
- W4210972925 cites W1914229355 @default.
- W4210972925 cites W1921213064 @default.
- W4210972925 cites W1932566429 @default.
- W4210972925 cites W1942869822 @default.
- W4210972925 cites W1960127159 @default.
- W4210972925 cites W1964267502 @default.
- W4210972925 cites W1965962344 @default.
- W4210972925 cites W1966137959 @default.
- W4210972925 cites W1966740309 @default.
- W4210972925 cites W1967938091 @default.
- W4210972925 cites W1969577103 @default.
- W4210972925 cites W1969897779 @default.
- W4210972925 cites W1970201566 @default.
- W4210972925 cites W1970540337 @default.
- W4210972925 cites W1971125474 @default.
- W4210972925 cites W1971386513 @default.
- W4210972925 cites W1971691895 @default.
- W4210972925 cites W1971899946 @default.
- W4210972925 cites W1971914532 @default.
- W4210972925 cites W1972937019 @default.
- W4210972925 cites W1972980827 @default.
- W4210972925 cites W1973444043 @default.
- W4210972925 cites W1973625682 @default.
- W4210972925 cites W1976709348 @default.
- W4210972925 cites W1977060648 @default.
- W4210972925 cites W1977456438 @default.
- W4210972925 cites W1977973668 @default.
- W4210972925 cites W1978446923 @default.
- W4210972925 cites W1979057766 @default.
- W4210972925 cites W1979336667 @default.
- W4210972925 cites W1981248553 @default.
- W4210972925 cites W1981416665 @default.
- W4210972925 cites W1982351864 @default.
- W4210972925 cites W1985531889 @default.
- W4210972925 cites W1987765015 @default.
- W4210972925 cites W1989563006 @default.
- W4210972925 cites W1990334258 @default.
- W4210972925 cites W1990861950 @default.
- W4210972925 cites W1994984215 @default.
- W4210972925 cites W1998123557 @default.
- W4210972925 cites W1998996879 @default.
- W4210972925 cites W1999403339 @default.
- W4210972925 cites W2000059848 @default.
- W4210972925 cites W2000067614 @default.
- W4210972925 cites W2000310751 @default.
- W4210972925 cites W2000537415 @default.
- W4210972925 cites W2001613399 @default.
- W4210972925 cites W2003661326 @default.
- W4210972925 cites W2005424736 @default.
- W4210972925 cites W2006779897 @default.
- W4210972925 cites W2007663198 @default.
- W4210972925 cites W2008472492 @default.
- W4210972925 cites W2008687669 @default.
- W4210972925 cites W2009686145 @default.
- W4210972925 cites W2009741791 @default.
- W4210972925 cites W2009743491 @default.
- W4210972925 cites W2012569032 @default.
- W4210972925 cites W2012634186 @default.
- W4210972925 cites W2014849086 @default.
- W4210972925 cites W2016303365 @default.
- W4210972925 cites W2017011895 @default.
- W4210972925 cites W2017763961 @default.
- W4210972925 cites W2019037591 @default.