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• W4210973332 abstract "Background Cutaneous leishmaniasis is caused by a parasitic infection and is considered one of the most serious skin diseases in many developing countries. Antimonials are the most commonly prescribed treatment but other drugs have been used with varying success. Objectives To assess the effects of treatments for Old World cutaneous leishmaniasis (OWCL). Search methods We searched the Cochrane Skin Group Specialised Register (April 2008), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 2, 2008), MEDLINE (2003‐April 2008), EMBASE (2005‐April 2008), CINAHL (1982‐August 2007), LILACS (from inception to April 2008) and ongoing trials databases (August 2007). Selection criteria Randomised controlled trials assessing treatments in immuno‐competent people with OWCL confirmed by smear, histology, culture or polymerase chain reaction. Data collection and analysis Two authors independently assessed trial quality and extracted data. Main results We included 49 trials involving 5559 participants. Reporting quality was generally poor and only two studies contained sufficiently similar data to pool. InLeishmania major infections, there was good RCT evidence of benefit of cure around 3 months after treatment when compared to placebo for 200 mg oral fluconazole (1 RCT n = 200, RR 2.78; 95% CI 1.86, 4.16), topical 15% paromomycin + 12% methylbenzethonium chloride (PR‐MBCL) (1 RCT n = 60, RR 3.09; 95% CI 1.14, 8.37) and photodynamic therapy (1 RCT n = 60, RR 7.02; 95% CI 3.80, 17.55). Topical PR‐MBCL was less efficacious than photodynamic therapy (1 RCT n = 65, RR 0.44; 95% CI 0.29, 0.66). Oral pentoxifylline was a good adjuvant therapy to intramuscular meglumine antimoniate (IMMA) when compared to IMMA plus placebo (1 RCT n = 64, RR 1.63; 95% CI 1.11, 2.39) InLeishmania tropica infections, there was good evidence of benefit for the use of 200 mg oral itraconazole for 6 weeks compared with placebo (1 RCT n = 20, RR 7.00; 95% CI 1.04, 46.95), for intralesional sodium stibogluconate (1 RCT n = 292, RR 2.62; 95% CI 1.78, 3.86), and for thermotherapy compared with intramuscular sodium stibogluconate (1 RCT n = 283, RR 2.99; 95% CI 2.04, 4.37). Authors' conclusions Most trials have been designed and reported poorly, resulting in a lack of evidence for potentially beneficial treatments. There is a desperate need for large well conducted studies that evaluate long‐term effects of current therapies. We suggest the creation of an international platform to improve quality and standardization of future trials in order to inform clinical practice." @default.
• W4210973332 created "2022-02-13" @default.
• W4210973332 creator A5020180402 @default.
• W4210973332 creator A5024500372 @default.
• W4210973332 creator A5053820308 @default.
• W4210973332 creator A5056417658 @default.
• W4210973332 date "2008-10-08" @default.
• W4210973332 modified "2023-10-06" @default.
• W4210973332 title "Interventions for Old World cutaneous leishmaniasis" @default.
• W4210973332 cites W1539233293 @default.
• W4210973332 cites W1611433784 @default.
• W4210973332 cites W165904758 @default.
• W4210973332 cites W1676761005 @default.
• W4210973332 cites W1768895040 @default.
• W4210973332 cites W180980477 @default.
• W4210973332 cites W1812354900 @default.
• W4210973332 cites W1903012462 @default.
• W4210973332 cites W1919856098 @default.
• W4210973332 cites W1963536763 @default.
• W4210973332 cites W1964293175 @default.
• W4210973332 cites W1964507537 @default.
• W4210973332 cites W1965801274 @default.
• W4210973332 cites W1966567564 @default.
• W4210973332 cites W1966801191 @default.
• W4210973332 cites W1969096248 @default.
• W4210973332 cites W1970562645 @default.
• W4210973332 cites W1971179316 @default.
• W4210973332 cites W1971302213 @default.
• W4210973332 cites W1974231736 @default.
• W4210973332 cites W1974904754 @default.
• W4210973332 cites W1975945034 @default.
• W4210973332 cites W1976804986 @default.
• W4210973332 cites W1981603584 @default.
• W4210973332 cites W1983498513 @default.
• W4210973332 cites W1985075719 @default.
• W4210973332 cites W1991804003 @default.
• W4210973332 cites W1995731773 @default.
• W4210973332 cites W1996958193 @default.
• W4210973332 cites W1998614988 @default.
• W4210973332 cites W2000998011 @default.
• W4210973332 cites W2001609499 @default.
• W4210973332 cites W2002559688 @default.
• W4210973332 cites W2002801308 @default.
• W4210973332 cites W2004504718 @default.
• W4210973332 cites W2005035808 @default.
• W4210973332 cites W2005641564 @default.
• W4210973332 cites W2006172552 @default.
• W4210973332 cites W2006768231 @default.
• W4210973332 cites W2009028465 @default.
• W4210973332 cites W2009309755 @default.
• W4210973332 cites W2013961199 @default.
• W4210973332 cites W2016564239 @default.
• W4210973332 cites W2017506149 @default.
• W4210973332 cites W2022831082 @default.
• W4210973332 cites W2023802867 @default.
• W4210973332 cites W2024711341 @default.
• W4210973332 cites W2026550283 @default.
• W4210973332 cites W2033890227 @default.
• W4210973332 cites W2035195315 @default.
• W4210973332 cites W2036526752 @default.
• W4210973332 cites W2038275192 @default.
• W4210973332 cites W2041653388 @default.
• W4210973332 cites W2044422589 @default.
• W4210973332 cites W2045156984 @default.
• W4210973332 cites W2049653283 @default.
• W4210973332 cites W2051621171 @default.
• W4210973332 cites W2054162993 @default.
• W4210973332 cites W2055165264 @default.
• W4210973332 cites W2058637638 @default.
• W4210973332 cites W2059638906 @default.
• W4210973332 cites W2059994174 @default.
• W4210973332 cites W2065594640 @default.
• W4210973332 cites W2067413001 @default.
• W4210973332 cites W2067930189 @default.
• W4210973332 cites W2069913623 @default.
• W4210973332 cites W2070000326 @default.
• W4210973332 cites W2072322177 @default.
• W4210973332 cites W2073335710 @default.
• W4210973332 cites W2074755706 @default.
• W4210973332 cites W2078643970 @default.
• W4210973332 cites W2081586053 @default.
• W4210973332 cites W2083037887 @default.
• W4210973332 cites W2085123566 @default.
• W4210973332 cites W2093248945 @default.
• W4210973332 cites W2094456817 @default.
• W4210973332 cites W2103110974 @default.
• W4210973332 cites W2103921559 @default.
• W4210973332 cites W2105009221 @default.
• W4210973332 cites W2107773768 @default.
• W4210973332 cites W2109046080 @default.
• W4210973332 cites W2111592855 @default.
• W4210973332 cites W2112778014 @default.
• W4210973332 cites W2112891358 @default.
• W4210973332 cites W2113687865 @default.
• W4210973332 cites W2131660005 @default.
• W4210973332 cites W2132667520 @default.
• W4210973332 cites W2132982599 @default.
• W4210973332 cites W2133825087 @default.
• W4210973332 cites W2135476804 @default.
• W4210973332 cites W2135809024 @default.

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