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- W4210975252 abstract "The inward rectifier potassium channel Kir2.1 (KCNJ2) is an important regulator of resting membrane potential in both excitable and non-excitable cells. The function of Kir2.1 channels is dependent on their lipid environment, including the availability of PI(4,5)P2, secondary anionic lipids, cholesterol and long-chain fatty acids acyl coenzyme A (LC-CoA). Endocannabinoids are a class of lipids that are naturally expressed in a variety of cells, including cardiac, neuronal, and immune cells. While these lipids are identified as ligands for cannabinoid receptors (CBRs), there is growing body of evidence that they can directly regulate the function of numerous ion channels independently of CBRs." @default.
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- W4210975252 date "2022-02-01" @default.
- W4210975252 modified "2023-09-26" @default.
- W4210975252 title "Endocannabinoid regulation of Kir2.1 inward rectifier potassium channels" @default.
- W4210975252 doi "https://doi.org/10.1016/j.bpj.2021.11.1554" @default.
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