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• W4210978875 endingPage "1195" @default.
• W4210978875 startingPage "1154" @default.
• W4210978875 abstract "Dysmotility of the small intestine and colon has a wide range of clinical manifestations, regardless of the underlying cause of the disorder. This chapter focuses on the small intestine, motility disorders of the colon that are manifested predominantly as constipation and megacolon. It also discusses the roles of endothelins and of gene mutation M918T in the maldevelopment of the enteric nervous system (ENS) and their role in Hirschsprung disease. Malnutrition develops in patients with severe dysmotility of the small intestine as the result of an inadequate intake of food and vomiting. In patients with severe dysmotility of the small intestine, chronic intestinal pseudoobstruction may develop. The chapter presents a case study which illustrates: (1) postnatal maturation of interstitial cells of Cajal (ICCs), (2) the importance of the conservative management of children with neonatal megacolon or pseudo obstruction, and (3) the importance of ICCs to the overall peristaltic function of the colon." @default.
• W4210978875 created "2022-02-13" @default.
• W4210978875 creator A5048600798 @default.
• W4210978875 date "2015-11-27" @default.
• W4210978875 modified "2023-10-17" @default.
• W4210978875 title "Dysmotility of the Small Intestine and Colon" @default.
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