FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210985300> ?p ?o ?g. }

• W4210985300 endingPage "34" @default.
• W4210985300 startingPage "1" @default.
• W4210985300 abstract "Baclofen and Lamotrigine via PLGA nanoparticles were developed for nose-to-brain delivery for the treatment of Neuropathic pain.Nanoparticles were prepared using the modified nano-precipitation method. The prepared NPs were characterised and further in vitro and in vivo studies were performed.The Bcf-Ltg-PLGA-NPs were ∼177.7 nm with >75%(w/w) drugs encapsulated. In vitro dissolution studies suggested zero-order release profiles following the Korsmeyer-Peppas model. In vitro cytotoxicity and staining studies on mammalian cells showed dose dependant cytotoxicity where nanoparticles were significantly less toxic (>95% cell-viability). ELISA studies on RAW-macrophages showed Bcf-Ltg-PLGA-NPs as a potential pro-inflammatory-cytokines inhibitor. In vivo gamma-scintigraphy studies on rats showed intra-nasal administration of 99mTc-Bcf-Ltg-PLGA-NPs showed Cmax 3.6%/g at Tmax = 1.5h with DTE% as 191.23% and DTP% = 38.61% in brain. Pharmacodynamics evaluations on C57BL/6J mice showed a significant reduction in licks/bites during inflammation-induced phase II pain.The findings concluded that the combination of these drugs into a single nanoparticle-based formulation has potential for pain management.Baclofen and Lamotrigine loaded PLGA nanoparticles were prepared with a size of 177.7nm, PDI 0.057 and Zeta Potential −15.8 mVIn vitro cell lines based studies showed dose dependant cytotoxicity and Bcf-Ltg-PLGA-NPs were found to be pro-inflammatory cytokines inhibitorsIn vivo Pharmacokinetic studies showed Cmax 3.6%/g at Tmax = 1.5 h with Drug Targeting Efficiency 191.23% and Drug Target Organ Transport 38.61% in the brain for prepared nanoparticlesIn vivo pharmacodynamics studies showed a significant reduction in licks/bites during inflammation-induced phase II pain." @default.
• W4210985300 created "2022-02-13" @default.
• W4210985300 creator A5008907153 @default.
• W4210985300 creator A5014782584 @default.
• W4210985300 creator A5019169840 @default.
• W4210985300 creator A5031670887 @default.
• W4210985300 creator A5043464027 @default.
• W4210985300 creator A5061629062 @default.
• W4210985300 creator A5068488089 @default.
• W4210985300 creator A5072180964 @default.
• W4210985300 creator A5073423146 @default.
• W4210985300 creator A5082661456 @default.
• W4210985300 date "2022-02-11" @default.
• W4210985300 modified "2023-10-16" @default.
• W4210985300 title "In vitro & In vivo evaluations of PLGA nanoparticle based combinatorial drug therapy for Baclofen and Lamotrigine for neuropathic pain management" @default.
• W4210985300 cites W1599016358 @default.
• W4210985300 cites W1814020593 @default.
• W4210985300 cites W1966433192 @default.
• W4210985300 cites W1968195678 @default.
• W4210985300 cites W1968661871 @default.
• W4210985300 cites W1975188780 @default.
• W4210985300 cites W1976332829 @default.
• W4210985300 cites W1983148605 @default.
• W4210985300 cites W2001933690 @default.
• W4210985300 cites W2002370810 @default.
• W4210985300 cites W2006324653 @default.
• W4210985300 cites W2016149234 @default.
• W4210985300 cites W2022835494 @default.
• W4210985300 cites W2027725351 @default.
• W4210985300 cites W2035333762 @default.
• W4210985300 cites W2035838068 @default.
• W4210985300 cites W2037702549 @default.
• W4210985300 cites W2050167321 @default.
• W4210985300 cites W2051246852 @default.
• W4210985300 cites W2063219038 @default.
• W4210985300 cites W2071521950 @default.
• W4210985300 cites W2074971761 @default.
• W4210985300 cites W2076437953 @default.
• W4210985300 cites W2087019065 @default.
• W4210985300 cites W2093705034 @default.
• W4210985300 cites W2093918270 @default.
• W4210985300 cites W2094310013 @default.
• W4210985300 cites W2103003626 @default.
• W4210985300 cites W2113945122 @default.
• W4210985300 cites W2114327665 @default.
• W4210985300 cites W2130141996 @default.
• W4210985300 cites W2136571523 @default.
• W4210985300 cites W2138831312 @default.
• W4210985300 cites W2139147593 @default.
• W4210985300 cites W2141415790 @default.
• W4210985300 cites W2146885452 @default.
• W4210985300 cites W2149984051 @default.
• W4210985300 cites W2153326832 @default.
• W4210985300 cites W2275576764 @default.
• W4210985300 cites W2326427176 @default.
• W4210985300 cites W2329021144 @default.
• W4210985300 cites W2522509600 @default.
• W4210985300 cites W2558423941 @default.
• W4210985300 cites W2570382747 @default.
• W4210985300 cites W2604759877 @default.
• W4210985300 cites W2790852710 @default.
• W4210985300 cites W283621748 @default.
• W4210985300 cites W2890089309 @default.
• W4210985300 cites W2922040645 @default.
• W4210985300 cites W3023923910 @default.
• W4210985300 cites W3099306023 @default.
• W4210985300 doi "https://doi.org/10.1080/02652048.2022.2041751" @default.
• W4210985300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35147068" @default.
• W4210985300 hasPublicationYear "2022" @default.
• W4210985300 type Work @default.
• W4210985300 citedByCount "1" @default.
• W4210985300 countsByYear W42109853002023 @default.
• W4210985300 crossrefType "journal-article" @default.
• W4210985300 hasAuthorship W4210985300A5008907153 @default.
• W4210985300 hasAuthorship W4210985300A5014782584 @default.
• W4210985300 hasAuthorship W4210985300A5019169840 @default.
• W4210985300 hasAuthorship W4210985300A5031670887 @default.
• W4210985300 hasAuthorship W4210985300A5043464027 @default.
• W4210985300 hasAuthorship W4210985300A5061629062 @default.
• W4210985300 hasAuthorship W4210985300A5068488089 @default.
• W4210985300 hasAuthorship W4210985300A5072180964 @default.
• W4210985300 hasAuthorship W4210985300A5073423146 @default.
• W4210985300 hasAuthorship W4210985300A5082661456 @default.
• W4210985300 hasConcept C109316439 @default.
• W4210985300 hasConcept C112705442 @default.
• W4210985300 hasConcept C150903083 @default.
• W4210985300 hasConcept C185592680 @default.
• W4210985300 hasConcept C202751555 @default.
• W4210985300 hasConcept C207001950 @default.
• W4210985300 hasConcept C22979827 @default.
• W4210985300 hasConcept C2777107010 @default.
• W4210985300 hasConcept C2780165375 @default.
• W4210985300 hasConcept C55493867 @default.
• W4210985300 hasConcept C71924100 @default.
• W4210985300 hasConcept C86803240 @default.
• W4210985300 hasConcept C98274493 @default.
• W4210985300 hasConceptScore W4210985300C109316439 @default.
• W4210985300 hasConceptScore W4210985300C112705442 @default.

• next