FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210990446> ?p ?o ?g. }

• W4210990446 abstract "Abstract Aim The variable results in clinical trials of adipose tissue-derived stem cells (ASCs) for chondral defects may be due to the different ex vivo culture conditions of the ASCs which are implanted to treat the lesions. We sought to determine the optimal in vitro chondrocyte co-culture condition that promotes infrapatellar fat pad-derived (IFPD) ASC chondrogenic gene expression in a novel co-culture combination. Methods In our study, we utilized an in vitro autologous co-culture of IFPD ASCs and articular chondrocytes derived from Kellgren–Lawrence Grade III/IV osteoarthritic human knee joints at ASC-to-chondrocyte seeding log ratios of 1:1, 10:1, and 100:1. Gene expression following in vitro co-culture was quantified by RT-qPCR with a panel comprising COL1A1, COL2A1, COL10A1, L-SOX5, SOX6, SOX9, ACAN, HSPG2, and COMP for chondrogenic gene expression. Results The chondrogenic gene expression profiles from co-cultures were greater than would be expected from an expression profile modeled from chondrocyte and ASC-only monocultures. Additionally, chondrogenic gene expression decreased with increasing ASC-to-chondrocyte seeding ratios. Conclusions These findings provide insight into the mechanisms underlying clinical ASC therapies and signifies that IFPD ASCs pre-conditioned by chondrocyte co-culture may have improved chondrogenic potential for cartilage repair. This model can help further understand IFPD ASCs in chondral and osteochondral repair and the chondrogenic pathways involved." @default.
• W4210990446 created "2022-02-13" @default.
• W4210990446 creator A5001331938 @default.
• W4210990446 creator A5008927098 @default.
• W4210990446 creator A5017898446 @default.
• W4210990446 creator A5029764708 @default.
• W4210990446 creator A5042446725 @default.
• W4210990446 date "2022-02-12" @default.
• W4210990446 modified "2023-09-27" @default.
• W4210990446 title "Infrapatellar fat pad adipose-derived stem cells co-cultured with articular chondrocytes from osteoarthritis patients exhibit increased chondrogenic gene expression" @default.
• W4210990446 cites W122755776 @default.
• W4210990446 cites W1521657513 @default.
• W4210990446 cites W1965665343 @default.
• W4210990446 cites W1967057044 @default.
• W4210990446 cites W1978851576 @default.
• W4210990446 cites W1980312552 @default.
• W4210990446 cites W1987543170 @default.
• W4210990446 cites W1988041518 @default.
• W4210990446 cites W2008399550 @default.
• W4210990446 cites W2009996996 @default.
• W4210990446 cites W2015050458 @default.
• W4210990446 cites W2015788548 @default.
• W4210990446 cites W2022104059 @default.
• W4210990446 cites W2025371271 @default.
• W4210990446 cites W2026734181 @default.
• W4210990446 cites W2072194111 @default.
• W4210990446 cites W2078594660 @default.
• W4210990446 cites W2086059908 @default.
• W4210990446 cites W2087370958 @default.
• W4210990446 cites W2088412241 @default.
• W4210990446 cites W2107277218 @default.
• W4210990446 cites W2110378444 @default.
• W4210990446 cites W2116579380 @default.
• W4210990446 cites W2123760352 @default.
• W4210990446 cites W2134171344 @default.
• W4210990446 cites W2137381294 @default.
• W4210990446 cites W2139826506 @default.
• W4210990446 cites W2150134228 @default.
• W4210990446 cites W2151347664 @default.
• W4210990446 cites W2154729178 @default.
• W4210990446 cites W2169607526 @default.
• W4210990446 cites W2192080449 @default.
• W4210990446 cites W2263013034 @default.
• W4210990446 cites W2268077420 @default.
• W4210990446 cites W2271661399 @default.
• W4210990446 cites W2282023422 @default.
• W4210990446 cites W230396661 @default.
• W4210990446 cites W2342732836 @default.
• W4210990446 cites W2595741404 @default.
• W4210990446 cites W2620738021 @default.
• W4210990446 cites W2746710261 @default.
• W4210990446 cites W2770892112 @default.
• W4210990446 cites W2789704095 @default.
• W4210990446 cites W2791152521 @default.
• W4210990446 cites W2805637759 @default.
• W4210990446 cites W2807502187 @default.
• W4210990446 cites W2811031443 @default.
• W4210990446 cites W2883409856 @default.
• W4210990446 cites W2891769404 @default.
• W4210990446 cites W2914800753 @default.
• W4210990446 cites W2919999424 @default.
• W4210990446 cites W2963509877 @default.
• W4210990446 cites W3014543671 @default.
• W4210990446 doi "https://doi.org/10.1186/s12964-021-00815-x" @default.
• W4210990446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35151341" @default.
• W4210990446 hasPublicationYear "2022" @default.
• W4210990446 type Work @default.
• W4210990446 citedByCount "5" @default.
• W4210990446 countsByYear W42109904462022 @default.
• W4210990446 countsByYear W42109904462023 @default.
• W4210990446 crossrefType "journal-article" @default.
• W4210990446 hasAuthorship W4210990446A5001331938 @default.
• W4210990446 hasAuthorship W4210990446A5008927098 @default.
• W4210990446 hasAuthorship W4210990446A5017898446 @default.
• W4210990446 hasAuthorship W4210990446A5029764708 @default.
• W4210990446 hasAuthorship W4210990446A5042446725 @default.
• W4210990446 hasBestOaLocation W42109904461 @default.
• W4210990446 hasConcept C104317684 @default.
• W4210990446 hasConcept C105702510 @default.
• W4210990446 hasConcept C126322002 @default.
• W4210990446 hasConcept C142724271 @default.
• W4210990446 hasConcept C150194340 @default.
• W4210990446 hasConcept C171089720 @default.
• W4210990446 hasConcept C185592680 @default.
• W4210990446 hasConcept C204787440 @default.
• W4210990446 hasConcept C2776164576 @default.
• W4210990446 hasConcept C2776610510 @default.
• W4210990446 hasConcept C2778486617 @default.
• W4210990446 hasConcept C2780550940 @default.
• W4210990446 hasConcept C2781403057 @default.
• W4210990446 hasConcept C28328180 @default.
• W4210990446 hasConcept C35496256 @default.
• W4210990446 hasConcept C55493867 @default.
• W4210990446 hasConcept C71924100 @default.
• W4210990446 hasConcept C86803240 @default.
• W4210990446 hasConcept C95444343 @default.
• W4210990446 hasConceptScore W4210990446C104317684 @default.
• W4210990446 hasConceptScore W4210990446C105702510 @default.
• W4210990446 hasConceptScore W4210990446C126322002 @default.
• W4210990446 hasConceptScore W4210990446C142724271 @default.

• next