Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211001330> ?p ?o ?g. }
- W4211001330 abstract "Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The ‘rise’ of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors, such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer, and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of the art of knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment. Colorectal cancer is a common cancer globally; its increased incidence over the past 60 years is associated with red meat consumption, smoking, alcohol intake and an ageing population. Here, Kuipers et al. describe the biology and treatment of colorectal cancers, and discuss the impact that screening will have on outcomes." @default.
- W4211001330 created "2022-02-13" @default.
- W4211001330 creator A5007344664 @default.
- W4211001330 creator A5017964935 @default.
- W4211001330 creator A5021152840 @default.
- W4211001330 creator A5026031837 @default.
- W4211001330 creator A5027839397 @default.
- W4211001330 creator A5049274840 @default.
- W4211001330 creator A5068477057 @default.
- W4211001330 creator A5081503066 @default.
- W4211001330 date "2015-11-05" @default.
- W4211001330 modified "2023-10-14" @default.
- W4211001330 title "Colorectal cancer" @default.
- W4211001330 cites W145172686 @default.
- W4211001330 cites W1504535992 @default.
- W4211001330 cites W1514834090 @default.
- W4211001330 cites W1516923186 @default.
- W4211001330 cites W1521660172 @default.
- W4211001330 cites W1527602422 @default.
- W4211001330 cites W1531266316 @default.
- W4211001330 cites W1539571840 @default.
- W4211001330 cites W1544851750 @default.
- W4211001330 cites W1568216332 @default.
- W4211001330 cites W1596817535 @default.
- W4211001330 cites W1633462988 @default.
- W4211001330 cites W1739333826 @default.
- W4211001330 cites W1822406468 @default.
- W4211001330 cites W1830195387 @default.
- W4211001330 cites W1859257957 @default.
- W4211001330 cites W1939720700 @default.
- W4211001330 cites W1963653242 @default.
- W4211001330 cites W1967622389 @default.
- W4211001330 cites W1969286055 @default.
- W4211001330 cites W1969373767 @default.
- W4211001330 cites W1971000774 @default.
- W4211001330 cites W1972376930 @default.
- W4211001330 cites W1972787853 @default.
- W4211001330 cites W1974413915 @default.
- W4211001330 cites W1974902120 @default.
- W4211001330 cites W1975476791 @default.
- W4211001330 cites W1981497640 @default.
- W4211001330 cites W1981886643 @default.
- W4211001330 cites W1983943352 @default.
- W4211001330 cites W1984200504 @default.
- W4211001330 cites W1984881598 @default.
- W4211001330 cites W1985745194 @default.
- W4211001330 cites W1987668608 @default.
- W4211001330 cites W1990204500 @default.
- W4211001330 cites W1991067721 @default.
- W4211001330 cites W1993123486 @default.
- W4211001330 cites W1994951109 @default.
- W4211001330 cites W1996167024 @default.
- W4211001330 cites W1998436936 @default.
- W4211001330 cites W1998516458 @default.
- W4211001330 cites W2000463468 @default.
- W4211001330 cites W2001258296 @default.
- W4211001330 cites W2002661711 @default.
- W4211001330 cites W2003946421 @default.
- W4211001330 cites W2004955567 @default.
- W4211001330 cites W2005348280 @default.
- W4211001330 cites W2009781085 @default.
- W4211001330 cites W2011743240 @default.
- W4211001330 cites W2011995257 @default.
- W4211001330 cites W2014776577 @default.
- W4211001330 cites W2018324712 @default.
- W4211001330 cites W2019568687 @default.
- W4211001330 cites W2020652146 @default.
- W4211001330 cites W2021293521 @default.
- W4211001330 cites W2022445223 @default.
- W4211001330 cites W2023458939 @default.
- W4211001330 cites W2023484878 @default.
- W4211001330 cites W2024830921 @default.
- W4211001330 cites W2026675000 @default.
- W4211001330 cites W2028328850 @default.
- W4211001330 cites W2032059652 @default.
- W4211001330 cites W2032627392 @default.
- W4211001330 cites W2033459915 @default.
- W4211001330 cites W2034269086 @default.
- W4211001330 cites W2034603533 @default.
- W4211001330 cites W2035008060 @default.
- W4211001330 cites W2037861078 @default.
- W4211001330 cites W2039587027 @default.
- W4211001330 cites W2040137805 @default.
- W4211001330 cites W2042113764 @default.
- W4211001330 cites W2042885655 @default.
- W4211001330 cites W2043407642 @default.
- W4211001330 cites W2046133119 @default.
- W4211001330 cites W2048769231 @default.
- W4211001330 cites W2057784612 @default.
- W4211001330 cites W2059543444 @default.
- W4211001330 cites W2061418426 @default.
- W4211001330 cites W2065330004 @default.
- W4211001330 cites W2065833903 @default.
- W4211001330 cites W2068191747 @default.
- W4211001330 cites W2068701323 @default.
- W4211001330 cites W2069377300 @default.
- W4211001330 cites W2073446948 @default.
- W4211001330 cites W2073533714 @default.
- W4211001330 cites W2074629176 @default.
- W4211001330 cites W2075803406 @default.