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• W4211012614 abstract "Inhalation of the enzyme dornase alfa reduces sputum viscosity and improves clinical outcomes of people with cystic fibrosis. This is an update of a previously published Cochrane Review.To determine whether the timing of dornase alfa inhalation (in relation to airway clearance techniques or morning versus evening inhalation) has an impact on objective and subjective measures of clinical efficacy in people with cystic fibrosis.Relevant randomised and quasi-randomised controlled trials were identified from the Cochrane Cystic Fibrosis Trials Register, Physiotherapy Evidence Database (PEDro), clinical trial registries and international cystic fibrosis conference proceedings.Date of the most recent search: 06 June 2018.Any trial of dornase alfa in people with cystic fibrosis where timing of inhalation was the randomised element in the trial with either: inhalation before compared to after airway clearance techniques; or morning compared to evening inhalation.Both authors independently selected trials, assessed risk of bias and extracted data with disagreements resolved by discussion. Relevant data were extracted and, where possible, meta-analysed.We identified 115 trial reports representing 55 trials, of which five trials (providing data on 122 participants) met our inclusion criteria. All five trials used a cross-over design. Intervention periods ranged from two to eight weeks. Four trials (98 participants) compared dornase alfa inhalation before versus after airway clearance techniques. Inhalation after instead of before airway clearance did not significantly change forced expiratory volume at one second (very-low quality evidence). Similarly, forced vital capacity (low-quality evidence) and quality of life (very-low quality evidence) were not significantly affected; forced expiratory flow at 25% was significantly worse with dornase alfa inhalation after airway clearance, mean difference -0.17 litres (95% confidence interval -0.28 to -0.05), based on the pooled data from two small trials in children (7 to 19 years) with well-preserved lung function. All other secondary outcomes were statistically non-significant.In one trial (25 participants), morning versus evening inhalation had no impact on lung function or symptoms (low-quality evidence).The current evidence derived from a small number of participants does not indicate that inhalation of dornase alfa after airway clearance techniques is more or less effective than the traditional recommendation to inhale nebulised dornase alfa 30 minutes prior to airway clearance techniques, for most outcomes. For children with well-preserved lung function, inhalation before airway clearance may be more beneficial for small airway function than inhalation after. However, this result relied on a measure with high variability and trials with variable follow-up. In the absence of strong evidence to indicate that one timing regimen is better than another, the timing of dornase alfa inhalation can be largely based on pragmatic reasons or individual preference with respect to the time of airway clearance and time of day. Further research is warranted." @default.
• W4211012614 created "2022-02-13" @default.
• W4211012614 creator A5006191933 @default.
• W4211012614 creator A5054173200 @default.
• W4211012614 date "2018-11-12" @default.
• W4211012614 modified "2023-09-27" @default.
• W4211012614 title "Timing of dornase alfa inhalation for cystic fibrosis" @default.
• W4211012614 cites W1492127057 @default.
• W4211012614 cites W175998601 @default.
• W4211012614 cites W1810640413 @default.
• W4211012614 cites W1872952081 @default.
• W4211012614 cites W1960686470 @default.
• W4211012614 cites W1963515595 @default.
• W4211012614 cites W1965385540 @default.
• W4211012614 cites W1970431627 @default.
• W4211012614 cites W1975609078 @default.
• W4211012614 cites W1975820788 @default.
• W4211012614 cites W1976867283 @default.
• W4211012614 cites W1978271506 @default.
• W4211012614 cites W1982251574 @default.
• W4211012614 cites W1991045784 @default.
• W4211012614 cites W1997182007 @default.
• W4211012614 cites W1997567908 @default.
• W4211012614 cites W2000875757 @default.
• W4211012614 cites W2006292526 @default.
• W4211012614 cites W2006739402 @default.
• W4211012614 cites W2006752980 @default.
• W4211012614 cites W2007479478 @default.
• W4211012614 cites W2010678373 @default.
• W4211012614 cites W2023546954 @default.
• W4211012614 cites W2023586232 @default.
• W4211012614 cites W2031789064 @default.
• W4211012614 cites W2036001221 @default.
• W4211012614 cites W2039548615 @default.
• W4211012614 cites W2041807185 @default.
• W4211012614 cites W2042259052 @default.
• W4211012614 cites W2046446743 @default.
• W4211012614 cites W2051130956 @default.
• W4211012614 cites W2054626218 @default.
• W4211012614 cites W2056935354 @default.
• W4211012614 cites W2057510647 @default.
• W4211012614 cites W2059734063 @default.
• W4211012614 cites W2061434168 @default.
• W4211012614 cites W2064024196 @default.
• W4211012614 cites W2096869184 @default.
• W4211012614 cites W2100786196 @default.
• W4211012614 cites W2102968146 @default.
• W4211012614 cites W2103436692 @default.
• W4211012614 cites W2110528741 @default.
• W4211012614 cites W2113032181 @default.
• W4211012614 cites W2113247257 @default.
• W4211012614 cites W2114074118 @default.
• W4211012614 cites W2119260499 @default.
• W4211012614 cites W2124879124 @default.
• W4211012614 cites W2125364344 @default.
• W4211012614 cites W2125435699 @default.
• W4211012614 cites W2127136998 @default.
• W4211012614 cites W2127818482 @default.
• W4211012614 cites W2128817585 @default.
• W4211012614 cites W2129637598 @default.
• W4211012614 cites W2129756193 @default.
• W4211012614 cites W2129772791 @default.
• W4211012614 cites W2130235475 @default.
• W4211012614 cites W2130690521 @default.
• W4211012614 cites W2133673354 @default.
• W4211012614 cites W2136652636 @default.
• W4211012614 cites W2144145895 @default.
• W4211012614 cites W2145410540 @default.
• W4211012614 cites W2148217897 @default.
• W4211012614 cites W2150399236 @default.
• W4211012614 cites W2153943794 @default.
• W4211012614 cites W2158898740 @default.
• W4211012614 cites W2165031309 @default.
• W4211012614 cites W2323350502 @default.
• W4211012614 cites W2333398204 @default.
• W4211012614 cites W2336714143 @default.
• W4211012614 cites W2414297191 @default.
• W4211012614 cites W2475052631 @default.
• W4211012614 cites W4211008131 @default.
• W4211012614 cites W4211109516 @default.
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• W4211012614 doi "https://doi.org/10.1002/14651858.cd007923.pub5" @default.
• W4211012614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30480755" @default.
• W4211012614 hasPublicationYear "2018" @default.
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