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• W4211026679 startingPage "199" @default.
• W4211026679 abstract "Isoflavones are polyphenolic compounds that structurally resemble mammalian estrogens. They are found in high amounts in soybeans and soy products, and in lower amounts in other foods. Common isoflavones in glycoside form include daidzin, genistin, and glycitin. After removal of a sugar moiety by enterocyte enzymes, isoflavones are absorbed from the gastrointestinal tract. The aglycones are referred to as daidzein, genistein, and glycitein. Gut microbes are also responsible for biotransformation of daidzein to equol and/or O-desmethylangolensin. Not all individuals have microbial environments that produce these compounds, and individuals can be classified into producer and nonproducer metabotypes. The associated metabotypes may also influence health, but this is an area requiring more extensive human studies. Isoflavone bioavailability can be influenced by type of food product (fermented vs unfermented), form of food product (liquid vs solid), and source (food vs supplement). Once absorbed, isoflavones can circulate and affect various target tissues. Well-studied physiological activities of isoflavones include hormonal, antioxidant, and antiinflammatory effects. There is limited evidence for isoflavone intake in particular populations that may have different baseline risk or metabolism, such as children or people with preexisting conditions. Isoflavones have been well studied in healthy, adult populations, and results of controlled trials and observational studies suggest that isoflavone intake may be beneficially associated with several health outcomes or with reduced risk of disease." @default.
• W4211026679 created "2022-02-13" @default.
• W4211026679 creator A5032767656 @default.
• W4211026679 date "2020-10-23" @default.
• W4211026679 modified "2023-10-12" @default.
• W4211026679 title "Isoflavones" @default.
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