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• W4211028699 abstract "Following a request from the European Commission to EFSA, the EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to re-evaluate the safety of annatto extracts, bixin-based and norbixin-based, when used as a food additive and to evaluate the safety of aqueous-processed bixin (Annatto E); solvent-extracted bixin (Annatto B); alkali-processed norbixin, acid-precipitated (Annatto F); alkali-processed norbixin, not acid-precipitated (Annatto G) and solvent-extracted norbixin (Annatto C) with the view to replace the currently authorised annatto extracts (E 160b). Given: (a) that read-across among the five bixin- and norbixin-based annatto extracts was feasible; (b) the availability of adequate 90-day toxicity studies with Annatto B, C, E and F; (c) the absence of concern for mutagenicity, carcinogenicity, reproductive and developmental toxicity of Annatto B, C, F and G, whereas the mutagenicity of Annatto E is equivocal, the Panel concluded that the safety of the currently authorised solvent-extracted bixin and norbixin (E 160b(i)), alkali-extracted annatto (E 160b(ii)) and oil-extracted annatto (E 160b(iii)), with the specifications defined in Commission Regulation (EU) No 231/2012, could not be assessed due to the lack of data, both in terms of identification and toxicological studies; solvent-extracted bixin (Annatto B), solvent-extracted norbixin (Annatto C), alkali-processed, acid-precipitated norbixin (Annatto F) and alkali-processed, not acid-precipitated norbixin (Annatto G and its norbixin salts) should comply with the specifications as recommended by the Panel. The toxicological database is sufficient to derive an acceptable daily intake (ADI) of 6 mg bixin/kg body weight (bw) per day and an ADI of 0.3 mg norbixin/kg bw per day. Exposure estimates for bixin were below the ADI for all population groups and for all refined exposure scenarios, including for the extension of use. For norbixin, exceedance was observed for the extension of use at the 95th percentile for some population groups." @default.
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• W4211028699 date "2016-08-01" @default.
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• W4211028699 title "The safety of annatto extracts (E 160b) as a food additive" @default.
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• W4211028699 doi "https://doi.org/10.2903/j.efsa.2016.4544" @default.
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