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- W4211030747 abstract "Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that is intensively expressed in the peripheral nerve system and involved in a variety of physiological and pathophysiological processes in mammals. Its activity is of great significance in transmitting pain or itch signals from peripheral sensory neurons to the central nervous system. The alteration or hypersensitivity of TRPV1 channel is well evidenced under various pathological conditions. Moreover, accumulative studies have revealed that TRPV1-expressing (TRPV1+) sensory neurons mediate the neuroimmune crosstalk by releasing neuropeptides to innervated tissues as well as immune cells. In the central projection, TRPV1+ terminals synapse with the secondary neurons for the transmission of pain and itch signalling. The intense involvement of TRPV1 and TRPV1+ neurons in pain and itch makes it a potential pharmaceutical target. Over decades, the basis of TRPV1 channel structure, the nature of its activity, and its modulation in pathological processes have been broadly studied and well documented. Herein, we highlight the role of TRPV1 and its associated neurons in sensing pain and itch. The fundamental understandings of TRPV1-involved nociception, pruriception, neurogenic inflammation, and cell-specific modulation will help bring out more effective strategies of TRPV1 modulation in treating pain- and itch-related diseases." @default.
- W4211030747 created "2022-02-13" @default.
- W4211030747 creator A5029787563 @default.
- W4211030747 creator A5045658917 @default.
- W4211030747 date "2021-01-01" @default.
- W4211030747 modified "2023-09-30" @default.
- W4211030747 title "TRPV1 in Pain and Itch" @default.
- W4211030747 cites W1511198581 @default.
- W4211030747 cites W1513929611 @default.
- W4211030747 cites W1623465125 @default.
- W4211030747 cites W1870440768 @default.
- W4211030747 cites W1901486182 @default.
- W4211030747 cites W1916136545 @default.
- W4211030747 cites W1954984364 @default.
- W4211030747 cites W1963857381 @default.
- W4211030747 cites W1964444312 @default.
- W4211030747 cites W1965018866 @default.
- W4211030747 cites W1967863888 @default.
- W4211030747 cites W1969655931 @default.
- W4211030747 cites W1969870004 @default.
- W4211030747 cites W1971066754 @default.
- W4211030747 cites W1973796039 @default.
- W4211030747 cites W1976437851 @default.
- W4211030747 cites W1982011911 @default.
- W4211030747 cites W1984042557 @default.
- W4211030747 cites W1987549117 @default.
- W4211030747 cites W1991857563 @default.
- W4211030747 cites W1993960807 @default.
- W4211030747 cites W1994814682 @default.
- W4211030747 cites W1997213628 @default.
- W4211030747 cites W1997380538 @default.
- W4211030747 cites W2005505879 @default.
- W4211030747 cites W2007034094 @default.
- W4211030747 cites W2007542365 @default.
- W4211030747 cites W2011677296 @default.
- W4211030747 cites W2014389293 @default.
- W4211030747 cites W2015834221 @default.
- W4211030747 cites W2020833052 @default.
- W4211030747 cites W2024642221 @default.
- W4211030747 cites W2029360579 @default.
- W4211030747 cites W2029608563 @default.
- W4211030747 cites W2032087136 @default.
- W4211030747 cites W2033072655 @default.
- W4211030747 cites W2034780599 @default.
- W4211030747 cites W2038164820 @default.
- W4211030747 cites W2039263844 @default.
- W4211030747 cites W2041702830 @default.
- W4211030747 cites W2043767564 @default.
- W4211030747 cites W2045626430 @default.
- W4211030747 cites W2046677990 @default.
- W4211030747 cites W2047393532 @default.
- W4211030747 cites W2050781058 @default.
- W4211030747 cites W2054124635 @default.
- W4211030747 cites W2056811697 @default.
- W4211030747 cites W2062606765 @default.
- W4211030747 cites W2070948590 @default.
- W4211030747 cites W2071564618 @default.
- W4211030747 cites W2072653944 @default.
- W4211030747 cites W2073035767 @default.
- W4211030747 cites W2075715972 @default.
- W4211030747 cites W2075720446 @default.
- W4211030747 cites W2076734646 @default.
- W4211030747 cites W2078187429 @default.
- W4211030747 cites W2082604829 @default.
- W4211030747 cites W2084062293 @default.
- W4211030747 cites W2086577243 @default.
- W4211030747 cites W2088102919 @default.
- W4211030747 cites W2088764206 @default.
- W4211030747 cites W2089494039 @default.
- W4211030747 cites W2090402561 @default.
- W4211030747 cites W2095397861 @default.
- W4211030747 cites W2098799628 @default.
- W4211030747 cites W2107063571 @default.
- W4211030747 cites W2107756388 @default.
- W4211030747 cites W2109293109 @default.
- W4211030747 cites W2109879418 @default.
- W4211030747 cites W2110156846 @default.
- W4211030747 cites W2110645568 @default.
- W4211030747 cites W2112868108 @default.
- W4211030747 cites W2113684190 @default.
- W4211030747 cites W2116139675 @default.
- W4211030747 cites W2118026478 @default.
- W4211030747 cites W2118866905 @default.
- W4211030747 cites W2119532085 @default.
- W4211030747 cites W2123815407 @default.
- W4211030747 cites W2123951881 @default.
- W4211030747 cites W2128598867 @default.
- W4211030747 cites W2129326126 @default.
- W4211030747 cites W2135906456 @default.
- W4211030747 cites W2141202838 @default.
- W4211030747 cites W2146734874 @default.
- W4211030747 cites W2147889176 @default.
- W4211030747 cites W2148570600 @default.
- W4211030747 cites W2149855043 @default.
- W4211030747 cites W2157848016 @default.
- W4211030747 cites W2157856809 @default.
- W4211030747 cites W2159721689 @default.
- W4211030747 cites W2162638563 @default.