FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211035268> ?p ?o ?g. }

• W4211035268 endingPage "105126" @default.
• W4211035268 startingPage "105126" @default.
• W4211035268 abstract "Effective cardiovascular tissue surrogates require high control of scaffold structural and mechanical features to match native tissue properties, which are dependent on tissue-specific mechanics, function heterogenicity, and morphology. Bridging scaffold processing variables with native tissue properties is recognized as a priority for advancing biomechanical performance of biomedical materials and, when translated to the clinical practice, their efficacy. Accordingly, this study selected electrospinning on a rotating cylindrical target as an apparatus of broad application and mapped the relationship between key processing variables and scaffold mechanics and structure. This information was combined with mechanical anisotropy ranges of interest for the three main categories of tissue surrogated in cardiovascular tissue engineering: heart valve leaflets, ventricle wall, and large diameter blood vessels. Specifically, three processing variables have been considered: the rotational velocity and the rastering velocity of the mandrel and the dry (single nozzle – polymer only) vs wet (double nozzle – polymer plus phosphate buffer saline solution) fabrication configuration. While the dry configuration is generally utilized to obtain micro-fiber based polymeric mats, the wet fabrication is representative of processing conditions utilized to incorporate cells, growth factors, or micro-particles within the fibrous scaffold matrix. Dry and wet processed electrospun mats were fabricated with tangential and rastering velocities within the 0.3–9.0 m/s and 0.16–8 cm/s range respectively. Biaxial mechanics, fiber network, and pore micro-architectures were measured for each combination of velocities and for each fabrication modality (dry and wet). Results allowed identification of the precise combination of rotational and rastering velocities, for both dry and wet conditions, that is able to recapitulate the native cardiovascular tissue anisotropy ratio. By adopting a simple and broadly utilized electrospinning layout, this study is meant to provide a repeatable and easy to access methodology to improve biomimicry of the in plane-mechanics of heart valve leaflets, ventricular wall, and large diameter blood vessels." @default.
• W4211035268 created "2022-02-13" @default.
• W4211035268 creator A5000458310 @default.
• W4211035268 creator A5009181920 @default.
• W4211035268 creator A5013023174 @default.
• W4211035268 creator A5024432409 @default.
• W4211035268 creator A5035922621 @default.
• W4211035268 creator A5058791393 @default.
• W4211035268 creator A5067981873 @default.
• W4211035268 creator A5075298005 @default.
• W4211035268 date "2022-04-01" @default.
• W4211035268 modified "2023-10-01" @default.
• W4211035268 title "Engineering in-plane mechanics of electrospun polyurethane scaffolds for cardiovascular tissue applications" @default.
• W4211035268 cites W1836828337 @default.
• W4211035268 cites W1966304033 @default.
• W4211035268 cites W1969529086 @default.
• W4211035268 cites W1979097177 @default.
• W4211035268 cites W1980894894 @default.
• W4211035268 cites W1980943128 @default.
• W4211035268 cites W1981924963 @default.
• W4211035268 cites W1984133400 @default.
• W4211035268 cites W1985151220 @default.
• W4211035268 cites W1988496850 @default.
• W4211035268 cites W1991231301 @default.
• W4211035268 cites W1992029307 @default.
• W4211035268 cites W1992064090 @default.
• W4211035268 cites W1993477295 @default.
• W4211035268 cites W1993895799 @default.
• W4211035268 cites W1995602590 @default.
• W4211035268 cites W1996481646 @default.
• W4211035268 cites W1996914913 @default.
• W4211035268 cites W1997552417 @default.
• W4211035268 cites W1998134287 @default.
• W4211035268 cites W1999227041 @default.
• W4211035268 cites W2006400766 @default.
• W4211035268 cites W2014156745 @default.
• W4211035268 cites W2019575274 @default.
• W4211035268 cites W2022577997 @default.
• W4211035268 cites W2031329146 @default.
• W4211035268 cites W2034686628 @default.
• W4211035268 cites W2035075843 @default.
• W4211035268 cites W2036484735 @default.
• W4211035268 cites W2038634187 @default.
• W4211035268 cites W2041043028 @default.
• W4211035268 cites W2047007407 @default.
• W4211035268 cites W2054070674 @default.
• W4211035268 cites W2055630021 @default.
• W4211035268 cites W2058406544 @default.
• W4211035268 cites W2059172905 @default.
• W4211035268 cites W2071806307 @default.
• W4211035268 cites W2071965745 @default.
• W4211035268 cites W2077354973 @default.
• W4211035268 cites W2078024459 @default.
• W4211035268 cites W2080472732 @default.
• W4211035268 cites W2086172466 @default.
• W4211035268 cites W2086483409 @default.
• W4211035268 cites W2087386685 @default.
• W4211035268 cites W2090237060 @default.
• W4211035268 cites W2092457622 @default.
• W4211035268 cites W2096316005 @default.
• W4211035268 cites W2110162714 @default.
• W4211035268 cites W2114882059 @default.
• W4211035268 cites W2115401452 @default.
• W4211035268 cites W2116149220 @default.
• W4211035268 cites W2125071760 @default.
• W4211035268 cites W2125267878 @default.
• W4211035268 cites W2137721915 @default.
• W4211035268 cites W2140276456 @default.
• W4211035268 cites W2147512638 @default.
• W4211035268 cites W2154306328 @default.
• W4211035268 cites W2156780019 @default.
• W4211035268 cites W2157248428 @default.
• W4211035268 cites W2163149000 @default.
• W4211035268 cites W2163784056 @default.
• W4211035268 cites W2333046529 @default.
• W4211035268 cites W2362472408 @default.
• W4211035268 cites W2735462795 @default.
• W4211035268 cites W2762789623 @default.
• W4211035268 cites W2889338819 @default.
• W4211035268 cites W2896805290 @default.
• W4211035268 cites W2897899783 @default.
• W4211035268 cites W2901883013 @default.
• W4211035268 cites W2944145496 @default.
• W4211035268 cites W2950764428 @default.
• W4211035268 cites W3084048358 @default.
• W4211035268 doi "https://doi.org/10.1016/j.jmbbm.2022.105126" @default.
• W4211035268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35180648" @default.
• W4211035268 hasPublicationYear "2022" @default.
• W4211035268 type Work @default.
• W4211035268 citedByCount "6" @default.
• W4211035268 countsByYear W42110352682022 @default.
• W4211035268 countsByYear W42110352682023 @default.
• W4211035268 crossrefType "journal-article" @default.
• W4211035268 hasAuthorship W4211035268A5000458310 @default.
• W4211035268 hasAuthorship W4211035268A5009181920 @default.
• W4211035268 hasAuthorship W4211035268A5013023174 @default.
• W4211035268 hasAuthorship W4211035268A5024432409 @default.
• W4211035268 hasAuthorship W4211035268A5035922621 @default.

• next