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• W4211036202 endingPage "1673" @default.
• W4211036202 startingPage "1577" @default.
• W4211036202 abstract "The sections in this article are: 1 Brief Historical Notes 2 Initial Findings 3 Isolation and Chemical Characterization 3.1 Structure of Low-Molecular-Weight ANF Peptides 3.2 Isolation of High-Molecular-Weight Forms 3.3 Nomenclature 4 Biosynthesis and Localization of ANF 4.1 Structures of the ANF Precursor, Messenger RNA, and Gene 4.2 Regulation of Gene Expression in Atrium 4.3 Biosynthetic Processing in Atrium 4.4 Gene Expression and Biosynthesis in Extraatrial Tissues 4.4.1 Cardiac Ventricles 4.4.2 Nervous System 4.4.3 Other Tissues 4.5 Homology with Other Proteins 5 Control of ANF Release 5.1 Atrial Distention 5.1.1 Cellular Mechanisms 5.1.2 Physiological Mechanisms Involving Atrial Distention 5.2 Atrial Contraction Frequency 5.3 Autonomic Influences on ANF Release 5.3.1 Adrenergic Agonists 5.3.2 Parasympathetic Agonists 5.3.3 Autonomic Input In Vivo 5.4 Other Vasoactive Agents 5.5 Other Factors 5.5.1 Plasma Osmolality and Sodium Concentration 5.5.2 Oxygen Tension 5.5.3 Opiate Agonists 5.5.4 Pituitary Factors 5.5.5 Diurnal Rhythm 5.5.6 Factors Affecting Biosynthesis 6 Pharmacokinetics and Metabolism 6.1 Pharmacokinetic Parameters 6.2 Sites of ANF Extraction 6.3 Metabolites of ANF 6.3.1 Generation of Metabolites In Vitro 6.4 Clearance Pathways 7 ANF Receptors and Second Messengers 7.1 Biochemical Characteristics of ANF Receptors 7.1.1 Receptor Heterogeneity 7.1.2 Receptor Ligands: Structure–Binding Relationships 7.1.3 Purification, Cloning, and Molecular Characteristics 7.2 Second Messengers of ANF Receptors 7.3 The Clearance Function of C-ANF Receptors 8 Functional Effects of ANF 8.1 Renal Actions 8.1.1 Effects of ANF in the Isolated Perfused Rat Kidney 8.1.2 Effects of ANF on the Renal Microvasculature 8.1.3 Renal Effects of ANF in Experimental Animals and in Humans 8.1.4 Glomerular Effects and Receptors 8.1.5 Tubular Effects and Receptors 8.1.6 How Does ANF Cause Natriuresis? 8.2 Effects on the Renin–Angiotensin–Aldosterone System 8.2.1 Inhibition of Renin Secretion 8.2.2 Antagonism of At II Action 8.2.3 Inhibition of Aldosterone Production 8.3 Effects on Other Steroid Pathways 8.3.1 Effects on Glucocorticoids 8.3.2 Effects on Gonadal Steroids 8.4 Effects on the Cardiovascular System 8.4.1 Effects on Vascular Smooth Muscle and Vascular Resistance 8.4.2 Effects on Fluid Compartmentalization 8.4.3 Effects on Autonomic Reflexes 8.4.4 Systemic Hemodynamic Effects 8.5 Central Nervous System Actions 8.5.1 Effects on Vasopressin Release and Action 8.5.2 Effects on Anterior Pituitary Hormone Secretion 8.5.3 Effects on Thirst, Salt Appetite, and Blood Pressure 9 Physiological Role of ANF 10 ANF in Pathological Conditions 10.1 Edematous Disorders 10.1.1 Congestive Heart Failure 10.1.2 Cirrhosis 10.1.3 Nephrotic Syndrome 10.1.4 Pathophysiological and Therapeutic Implications 10.2 Renal Failure 10.3 Hypertensive Disorders 10.4 Preeclampsia 10.5 Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) 10.6 Bartter's Syndrome 10.7 Other Disorders 10.7.1 Supraventricular Tachyarrhythmias 10.7.2 Diabetes Mellitus 10.7.3 Thyroid Disease 10.7.4 Pulmonary Disease 11 conclusion11 Conclusions" @default.
• W4211036202 created "2022-02-13" @default.
• W4211036202 creator A5047363033 @default.
• W4211036202 creator A5076743084 @default.
• W4211036202 date "1992-12-01" @default.
• W4211036202 modified "2023-10-15" @default.
• W4211036202 title "Atrial Natriuretic Factor" @default.
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