Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211036981> ?p ?o ?g. }
- W4211036981 abstract "Significance The role of STING in maintaining glucose homeostasis remains unknown. Herein, using global and β-cell–specific STING knockout mouse models, we revealed a distinct role of STING in the regulation of glucose homeostasis through β-cells and peripheral tissues. Specially, while global STING knockout beneficially alleviated insulin resistance and glucose intolerance induced by high-fat diet, it surprisingly impaired islet glucose-stimulated insulin secretion (GSIS). Further analyses revealed that STING deficiency down-regulated expression of β-cell key transcription factor Pax6, impairing Pax6 nuclear localization and binding activity to the promoters of its target genes, including Glut2 and Abcc8, causing impaired GSIS. These data highlight pathophysiological significance of fine-tuned STING signaling in β-cells and insulin target tissues for maintaining glucose homeostasis." @default.
- W4211036981 created "2022-02-13" @default.
- W4211036981 creator A5000102085 @default.
- W4211036981 creator A5014771162 @default.
- W4211036981 creator A5018010593 @default.
- W4211036981 creator A5022625306 @default.
- W4211036981 creator A5028184115 @default.
- W4211036981 creator A5030507461 @default.
- W4211036981 creator A5038129578 @default.
- W4211036981 creator A5040985293 @default.
- W4211036981 creator A5050613147 @default.
- W4211036981 creator A5051936772 @default.
- W4211036981 creator A5061279558 @default.
- W4211036981 creator A5091519984 @default.
- W4211036981 date "2022-02-10" @default.
- W4211036981 modified "2023-09-30" @default.
- W4211036981 title "A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion" @default.
- W4211036981 cites W1968178474 @default.
- W4211036981 cites W1973045246 @default.
- W4211036981 cites W2005118791 @default.
- W4211036981 cites W2014677321 @default.
- W4211036981 cites W2015879727 @default.
- W4211036981 cites W2021341670 @default.
- W4211036981 cites W2028107828 @default.
- W4211036981 cites W2033906871 @default.
- W4211036981 cites W2035232303 @default.
- W4211036981 cites W2035618305 @default.
- W4211036981 cites W2037554972 @default.
- W4211036981 cites W2041345682 @default.
- W4211036981 cites W2052739037 @default.
- W4211036981 cites W2052882363 @default.
- W4211036981 cites W2060004514 @default.
- W4211036981 cites W2065543070 @default.
- W4211036981 cites W2070176899 @default.
- W4211036981 cites W2072171296 @default.
- W4211036981 cites W2083147016 @default.
- W4211036981 cites W2088160164 @default.
- W4211036981 cites W2108585459 @default.
- W4211036981 cites W2117757143 @default.
- W4211036981 cites W2141224543 @default.
- W4211036981 cites W2152289968 @default.
- W4211036981 cites W2155080214 @default.
- W4211036981 cites W2170551349 @default.
- W4211036981 cites W2171808845 @default.
- W4211036981 cites W2179438025 @default.
- W4211036981 cites W2191790139 @default.
- W4211036981 cites W2220279767 @default.
- W4211036981 cites W2286407307 @default.
- W4211036981 cites W2398393547 @default.
- W4211036981 cites W2522054472 @default.
- W4211036981 cites W2560349316 @default.
- W4211036981 cites W2569672282 @default.
- W4211036981 cites W2597238176 @default.
- W4211036981 cites W2605083661 @default.
- W4211036981 cites W2756955933 @default.
- W4211036981 cites W2765921352 @default.
- W4211036981 cites W2766044142 @default.
- W4211036981 cites W2775731768 @default.
- W4211036981 cites W2795875233 @default.
- W4211036981 cites W2888230285 @default.
- W4211036981 cites W2889136720 @default.
- W4211036981 cites W2892170438 @default.
- W4211036981 cites W2905091095 @default.
- W4211036981 cites W2920191405 @default.
- W4211036981 cites W2921261426 @default.
- W4211036981 cites W2945993260 @default.
- W4211036981 cites W2953056615 @default.
- W4211036981 cites W2958830246 @default.
- W4211036981 cites W2989982619 @default.
- W4211036981 cites W3013112907 @default.
- W4211036981 cites W3025723753 @default.
- W4211036981 cites W3028450214 @default.
- W4211036981 cites W3047708026 @default.
- W4211036981 cites W3118757543 @default.
- W4211036981 cites W3174972248 @default.
- W4211036981 doi "https://doi.org/10.1073/pnas.2101848119" @default.
- W4211036981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35145023" @default.
- W4211036981 hasPublicationYear "2022" @default.
- W4211036981 type Work @default.
- W4211036981 citedByCount "17" @default.
- W4211036981 countsByYear W42110369812022 @default.
- W4211036981 countsByYear W42110369812023 @default.
- W4211036981 crossrefType "journal-article" @default.
- W4211036981 hasAuthorship W4211036981A5000102085 @default.
- W4211036981 hasAuthorship W4211036981A5014771162 @default.
- W4211036981 hasAuthorship W4211036981A5018010593 @default.
- W4211036981 hasAuthorship W4211036981A5022625306 @default.
- W4211036981 hasAuthorship W4211036981A5028184115 @default.
- W4211036981 hasAuthorship W4211036981A5030507461 @default.
- W4211036981 hasAuthorship W4211036981A5038129578 @default.
- W4211036981 hasAuthorship W4211036981A5040985293 @default.
- W4211036981 hasAuthorship W4211036981A5050613147 @default.
- W4211036981 hasAuthorship W4211036981A5051936772 @default.
- W4211036981 hasAuthorship W4211036981A5061279558 @default.
- W4211036981 hasAuthorship W4211036981A5091519984 @default.
- W4211036981 hasBestOaLocation W42110369811 @default.
- W4211036981 hasConcept C104317684 @default.
- W4211036981 hasConcept C126322002 @default.
- W4211036981 hasConcept C127413603 @default.
- W4211036981 hasConcept C134018914 @default.