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• W4211044037 abstract "Abstract Molecular genetic studies of schizophrenia are built upon the firm foundations of reliable diagnostic methodology and a wealth of genetic epidemiological data. The fact that most, if not all, disease genes apparently have only moderate or small effect sizes on the risk of developing the disorder has proved a challenge to their discovery, as it has in the study of other common diseases. However, the sample and technological resources combined with the reagents generated by the human genome project have begun to make complex disease gene discovery studies feasible. This chapter discusses the potential regions of linkage and two associated chromosomal abnormalities that have been identified for schizophrenia, and debates the accumulating evidence favoring several positional candidate genes. Although in no case has the causative variant(s) been identified, the current findings suggest that the positional genetic approach to schizophrenia is at last bearing fruit, and offer grounds for considerable optimism." @default.
• W4211044037 created "2022-02-13" @default.
• W4211044037 creator A5059458620 @default.
• W4211044037 creator A5081027762 @default.
• W4211044037 date "2007-03-02" @default.
• W4211044037 modified "2023-10-18" @default.
• W4211044037 title "Molecular Genetics of Schizophrenia" @default.
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