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- W4211058510 abstract "Immunotoxicology has evolved over the last 30 years as a specialty within toxicology that brings together knowledge from basic immunology, molecular biology, microbiology, pharmacology, and physiology. As a discipline, immunotoxicology involves the study of adverse effects that xenobiotics have on the immune system. An adverse immune response in the form of hypersensitivity is one of the most frequent safety causes for withdrawal of drugs that have already made it to the market and accounts for approximately 15 percent of adverse reactions to xenobiotics. The important cells of the adaptive immune system are the lymphocytes and antigen-presenting cells (APCs) that are part of nonspecific immunity. The lymphocytes, which originate from pluripotent stem cells located in the hematopoietic tissues of the liver and bone marrow, are composed of two general cell types: T and B cells. Although the immune system has a well-developed reserve capacity, some of these systems may act synergistically rather than independently." @default.
- W4211058510 created "2022-02-13" @default.
- W4211058510 date "2016-10-31" @default.
- W4211058510 modified "2023-09-26" @default.
- W4211058510 title "IMMUNOTOXICOLOGY IN DRUG DEVELOPMENT" @default.
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- W4211058510 doi "https://doi.org/10.1002/9781119097440.ch11" @default.
- W4211058510 hasPublicationYear "2016" @default.
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