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- W4211058898 abstract "Abstract In vitro selection of remdesivir-resistant SARS-CoV-2 revealed the emergence of a V166L substitution, located outside of the polymerase active site of the nsp12 protein, after 9 passages. V166L remained the only nsp12 substitution after 17 passages at a final concentration of 10 µM RDV, conferring a 2.3-fold increase in EC 50 . When V166L was introduced into a recombinant SARS-CoV-2 virus, a 1.5-fold increase in EC 50 was observed, indicating a high in vitro barrier to RDV resistance." @default.
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- W4211058898 date "2022-02-12" @default.
- W4211058898 modified "2023-10-16" @default.
- W4211058898 title "In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance" @default.
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- W4211058898 doi "https://doi.org/10.1101/2022.02.07.479493" @default.
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