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• W4211060258 abstract "In this experimental study, the authors investigated whether fat placement in the pocket during implant insertion affects capsule formation.Twenty albino Wistar rats, 400 g each, were used. The rats were divided into two groups, A and B, of 10 rats each. At the dorsum of each rat, four pockets (2 × 2 cm each) were dissected, two left and two right of the midline. In each pocket, a 1 × 1 × 1.5-cm silicone implant was inserted. In the two left pockets, only silicone implants were placed (control). In the two right pockets, 0.4 ml of fat was injected around the implant. Animals in group A were killed 2 months postoperatively, and those in group B were killed 4 months postoperatively. The implants were dissected with the capsule and sent for histopathologic examination.The data of the fat transfer group was compared with control in groups A and B. Capsule thickness, neovascularization, myofibroblast layer thickness, and mast cell population demonstrated no statistically significant difference in either group A (p = 0.385, p = 0.862, p = 0.874, and p = 0.210, respectively) or group B (p = 0.338, p = 1.000, p = 0.288, and p = 0.344, respectively). Inflammation was statistically significantly less (p = 0.07) at 4 months (group B) in the fat transfer group compared to the control group. Likewise, cellularity was statistically significantly less (p = 0.019) at 4 months for the fat transfer group compared with the control group.Fat injection in the pocket during implant placement may reduce inflammation and cellularity of capsules and predispose to faster capsule maturation.Fat transfer around implants may positively affect implant-based breast reconstruction and/or breast augmentation." @default.
• W4211060258 created "2022-02-13" @default.
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• W4211060258 date "2022-02-03" @default.
• W4211060258 modified "2023-10-18" @default.
• W4211060258 title "Investigation of Autologous Fat Transfer in Capsule Formation around Silicone Implants in a Rat Model" @default.
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• W4211060258 doi "https://doi.org/10.1097/prs.0000000000008923" @default.
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