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- W4211062222 abstract "Formation of the auto-inhibited super-relaxed (SRX) state of cardiac myosin is thought to be crucial for regulating contraction, relaxation, and energy conservation in the heart. We found that a single point mutation, E525K, associated with dilated cardiomyopathy (DCM) dramatically enhances the stability of the SRX state. We expressed human cardiac myosin containing the subfragment 1 domain, 15 heptads of the subfragment 2 coiled-coil region and a leucine zipper that facilitates dimerization, as well as a C-terminal GFP tag (M2β 15HPZ.GFP)." @default.
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- W4211062222 date "2022-02-01" @default.
- W4211062222 modified "2023-10-02" @default.
- W4211062222 title "Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting heads motif and super-relaxed state of myosin" @default.
- W4211062222 doi "https://doi.org/10.1016/j.bpj.2021.11.1439" @default.
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