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- W4211063268 endingPage "234" @default.
- W4211063268 startingPage "223" @default.
- W4211063268 abstract "High-dose conditioning regimens given prior to hematopoietic cell transplantation (HCT) are designed primarily for tumor eradication but also provide immunosuppression, ensuring engraftment of allogeneic stem cells. Most regimens have been developed empirically using phase 1 trials to identify the highest doses of total body irradiation and chemotherapy that can be tolerated in order to maximize tumor kill without unacceptable toxicity. Many groups have moved away from irradiation owing to concerns over toxicities; however, few studies have directly compared outcomes after conditioning with either irradiation or chemotherapy regimens. Despite the widespread use of high-dose regimens for over 30 years, relapse remains the most important reason for treatment failure after HCT. Since most high-dose regimens are already at the maximum tolerated doses, future progress in the development of conditioning regimens will depend on the application of targeted delivery of irradiation or chemotherapy in order to improve cytoreduction while minimizing off target toxicities." @default.
- W4211063268 created "2022-02-13" @default.
- W4211063268 creator A5071375525 @default.
- W4211063268 date "2015-10-16" @default.
- W4211063268 modified "2023-10-16" @default.
- W4211063268 title "High‐dose Preparatory Regimens" @default.
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