Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211069181> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W4211069181 abstract "The pathogenic yeast Cryptococcus neoformans causes nearly 200,000 deaths annually in immunocompromised individuals. Cryptococcus cells can undergo substantial morphological change during mammalian infection, including increased capsule and cell size, the release of shed capsule, and the production of titan (> 10 µm), micro (< 2 µm) and irregular cells. We examined phenotypic variation under conditions designed to simulate in vivo stress in a collection of nine lineages derived from the C. neoformans type strain H99. These lineages are highly genetically similar but have a range of virulence levels. Strains from hypervirulent lineages had a larger average capsule size, greater variation in cell size, and an increased production of micro cells and shed capsule. We tested whether disruption of SGF29, which encodes a component of the SAGA histone acetylation complex that has previously been implicated in the hypervirulence of some lineages, might also have a role in the production of morphological variants. Deletion of SGF29 in a lineage with intermediate virulence substantially increased its production of micro cells and released capsule, consistent with a switch to hypervirulence. We further examined SGF29 in a set of 52 clinical isolates and found loss-of-function mutations were significantly correlated with patient death. Expansion of a TA repeat in the second intron of SGF29 was positively correlated with cell and capsule size, suggesting it may also affect Sgf29 function. This study extends the evidence for a link between pleomorphism and virulence in Cryptococcus, with a likely role for epigenetic mechanisms mediated by SAGA-induced histone acetylation." @default.
- W4211069181 created "2022-02-13" @default.
- W4211069181 creator A5061314552 @default.
- W4211069181 creator A5061430716 @default.
- W4211069181 creator A5065433879 @default.
- W4211069181 date "2022-02-10" @default.
- W4211069181 modified "2023-10-16" @default.
- W4211069181 title "Lineages derived from Cryptococcus neoformans type strain H99 support a link between the capacity to be pleomorphic and virulence" @default.
- W4211069181 doi "https://doi.org/10.1101/2022.02.09.479843" @default.
- W4211069181 hasPublicationYear "2022" @default.
- W4211069181 type Work @default.
- W4211069181 citedByCount "0" @default.
- W4211069181 crossrefType "posted-content" @default.
- W4211069181 hasAuthorship W4211069181A5061314552 @default.
- W4211069181 hasAuthorship W4211069181A5061430716 @default.
- W4211069181 hasAuthorship W4211069181A5065433879 @default.
- W4211069181 hasBestOaLocation W42110691811 @default.
- W4211069181 hasConcept C104317684 @default.
- W4211069181 hasConcept C127716648 @default.
- W4211069181 hasConcept C2777893358 @default.
- W4211069181 hasConcept C2781090273 @default.
- W4211069181 hasConcept C54355233 @default.
- W4211069181 hasConcept C60987743 @default.
- W4211069181 hasConcept C64927066 @default.
- W4211069181 hasConcept C86803240 @default.
- W4211069181 hasConcept C89423630 @default.
- W4211069181 hasConceptScore W4211069181C104317684 @default.
- W4211069181 hasConceptScore W4211069181C127716648 @default.
- W4211069181 hasConceptScore W4211069181C2777893358 @default.
- W4211069181 hasConceptScore W4211069181C2781090273 @default.
- W4211069181 hasConceptScore W4211069181C54355233 @default.
- W4211069181 hasConceptScore W4211069181C60987743 @default.
- W4211069181 hasConceptScore W4211069181C64927066 @default.
- W4211069181 hasConceptScore W4211069181C86803240 @default.
- W4211069181 hasConceptScore W4211069181C89423630 @default.
- W4211069181 hasLocation W42110691811 @default.
- W4211069181 hasOpenAccess W4211069181 @default.
- W4211069181 hasPrimaryLocation W42110691811 @default.
- W4211069181 hasRelatedWork W1933182366 @default.
- W4211069181 hasRelatedWork W1963570707 @default.
- W4211069181 hasRelatedWork W1977852240 @default.
- W4211069181 hasRelatedWork W2005800004 @default.
- W4211069181 hasRelatedWork W2036920350 @default.
- W4211069181 hasRelatedWork W2095908222 @default.
- W4211069181 hasRelatedWork W2119787932 @default.
- W4211069181 hasRelatedWork W2137300425 @default.
- W4211069181 hasRelatedWork W2171788590 @default.
- W4211069181 hasRelatedWork W2794083788 @default.
- W4211069181 isParatext "false" @default.
- W4211069181 isRetracted "false" @default.
- W4211069181 workType "article" @default.