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- W4211069897 abstract "Propionibacterium acnes (P. acnes) is a major pathogen of acne vulgaris. The traditional Chinese medicine (TCM) compound prescription, Dian Dao San (DDS), is effective for treating P. acnes. Previous clinical work by our team demonstrated that improved Dian Dao San (IDDS) has better antibacterial effects. However, the mechanism of IDDS inhibition of P. acnes is still unknown. Hence, the isobaric tags for relative and absolute quantitation (iTRAQ) technology was applied to explore the antibacterial mechanism of IDDS against P. acnes. Our results suggested that the antibacterial mechanism of IDDS was related to the glycolytic pathway. gap, pgk, and tpiA enzymes were found to be potential target proteins in the bacterial glycolytic pathway as an antibacterial mechanism of inhibition. In addition, SEM and TEM analyses revealed that IDDS may destruct bacterial plasma membrane and cell wall. The results provide a reliable, direct, and scientific theoretical basis for wide application of IDDS." @default.
- W4211069897 created "2022-02-13" @default.
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- W4211069897 date "2022-02-09" @default.
- W4211069897 modified "2023-10-14" @default.
- W4211069897 title "Proteomic Analysis of the Antibacterial Effect of Improved Dian Dao San against Propionibacterium acnes" @default.
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- W4211069897 doi "https://doi.org/10.1155/2022/3855702" @default.
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