FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211072043> ?p ?o ?g. }

• W4211072043 endingPage "300" @default.
• W4211072043 startingPage "289" @default.
• W4211072043 abstract "Muscarinic M3 (M3 ) receptors mediate cholinergic smooth muscle contraction of the bladder. Current drugs targeting bladder M3 receptors for micturition disorders have a risk of cholinergic side effects due to excessive receptor activation and insufficient selectivity. We investigated the effect of ASP8302, a novel positive allosteric modulator (PAM) of M3 receptors, on bladder function in rats.Modulation of carbachol-induced increases in intracellular Ca2+ was assessed in cells expressing rat muscarinic receptors. Potentiation of bladder contractions was evaluated using isolated rat bladder strips and by measuring intravesical pressure in anesthetized rats. Conscious cystometry was performed to investigate the effects on residual urine volume and voiding efficiency in rat voiding dysfunction models induced by the α1 -adrenoceptor agonist midodrine and muscarinic receptor antagonist atropine, and bladder outlet obstruction. To assess potential side effects, the number of stools and tracheal insufflation pressure were measured in conscious and anesthetized rats, respectively.ASP8302 demonstrated PAM effects on the rat M3 receptor in cell assays, and augmented cholinergic bladder contractions both in vivo and in vitro. ASP8302 improved voiding efficiency and reduced residual urine volume in two voiding dysfunction models as effectively as distigmine bromide, but unlike distigmine bromide did not affect the number of stools or tracheal insufflation pressure.Our results in rats indicate that ASP8302 improves voiding dysfunction by potentiating bladder contraction with fewer effects on cholinergic responses in other organs, and suggest a potential advantage over current cholinomimetic drugs for treating micturition disorders caused by insufficient bladder contraction." @default.
• W4211072043 created "2022-02-13" @default.
• W4211072043 creator A5000914917 @default.
• W4211072043 creator A5004024254 @default.
• W4211072043 creator A5011624496 @default.
• W4211072043 creator A5022700904 @default.
• W4211072043 creator A5023346022 @default.
• W4211072043 creator A5031136197 @default.
• W4211072043 creator A5033439242 @default.
• W4211072043 creator A5071947192 @default.
• W4211072043 creator A5072006202 @default.
• W4211072043 creator A5087163870 @default.
• W4211072043 date "2022-02-12" @default.
• W4211072043 modified "2023-09-26" @default.
• W4211072043 title "Muscarinic <scp>M₃</scp> positive allosteric modulator <scp>ASP8302</scp> enhances bladder contraction and improves voiding dysfunction in rats" @default.
• W4211072043 cites W1486034831 @default.
• W4211072043 cites W1489146791 @default.
• W4211072043 cites W1580343424 @default.
• W4211072043 cites W1583297295 @default.
• W4211072043 cites W1886006583 @default.
• W4211072043 cites W1938705645 @default.
• W4211072043 cites W1971279101 @default.
• W4211072043 cites W1981173490 @default.
• W4211072043 cites W1989309123 @default.
• W4211072043 cites W2003002002 @default.
• W4211072043 cites W2003736358 @default.
• W4211072043 cites W2008969125 @default.
• W4211072043 cites W2028310558 @default.
• W4211072043 cites W2034868648 @default.
• W4211072043 cites W2036170730 @default.
• W4211072043 cites W2051994079 @default.
• W4211072043 cites W2073324778 @default.
• W4211072043 cites W2108650042 @default.
• W4211072043 cites W2124540551 @default.
• W4211072043 cites W2130777538 @default.
• W4211072043 cites W2131282622 @default.
• W4211072043 cites W2136878364 @default.
• W4211072043 cites W2780925614 @default.
• W4211072043 cites W2891053745 @default.
• W4211072043 cites W2908730573 @default.
• W4211072043 cites W2921354691 @default.
• W4211072043 cites W3023342097 @default.
• W4211072043 cites W3091905655 @default.
• W4211072043 cites W3144118735 @default.
• W4211072043 cites W3181582542 @default.
• W4211072043 doi "https://doi.org/10.1111/luts.12430" @default.
• W4211072043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35150075" @default.
• W4211072043 hasPublicationYear "2022" @default.
• W4211072043 type Work @default.
• W4211072043 citedByCount "0" @default.
• W4211072043 crossrefType "journal-article" @default.
• W4211072043 hasAuthorship W4211072043A5000914917 @default.
• W4211072043 hasAuthorship W4211072043A5004024254 @default.
• W4211072043 hasAuthorship W4211072043A5011624496 @default.
• W4211072043 hasAuthorship W4211072043A5022700904 @default.
• W4211072043 hasAuthorship W4211072043A5023346022 @default.
• W4211072043 hasAuthorship W4211072043A5031136197 @default.
• W4211072043 hasAuthorship W4211072043A5033439242 @default.
• W4211072043 hasAuthorship W4211072043A5071947192 @default.
• W4211072043 hasAuthorship W4211072043A5072006202 @default.
• W4211072043 hasAuthorship W4211072043A5087163870 @default.
• W4211072043 hasConcept C126322002 @default.
• W4211072043 hasConcept C134018914 @default.
• W4211072043 hasConcept C142724271 @default.
• W4211072043 hasConcept C163415756 @default.
• W4211072043 hasConcept C170493617 @default.
• W4211072043 hasConcept C175768497 @default.
• W4211072043 hasConcept C185592680 @default.
• W4211072043 hasConcept C204787440 @default.
• W4211072043 hasConcept C22885893 @default.
• W4211072043 hasConcept C2775859210 @default.
• W4211072043 hasConcept C2776961477 @default.
• W4211072043 hasConcept C2778616617 @default.
• W4211072043 hasConcept C2778938600 @default.
• W4211072043 hasConcept C2778941218 @default.
• W4211072043 hasConcept C2778988552 @default.
• W4211072043 hasConcept C2779762690 @default.
• W4211072043 hasConcept C2780080261 @default.
• W4211072043 hasConcept C2780616540 @default.
• W4211072043 hasConcept C33789571 @default.
• W4211072043 hasConcept C47488739 @default.
• W4211072043 hasConcept C71924100 @default.
• W4211072043 hasConcept C77411442 @default.
• W4211072043 hasConcept C98274493 @default.
• W4211072043 hasConceptScore W4211072043C126322002 @default.
• W4211072043 hasConceptScore W4211072043C134018914 @default.
• W4211072043 hasConceptScore W4211072043C142724271 @default.
• W4211072043 hasConceptScore W4211072043C163415756 @default.
• W4211072043 hasConceptScore W4211072043C170493617 @default.
• W4211072043 hasConceptScore W4211072043C175768497 @default.
• W4211072043 hasConceptScore W4211072043C185592680 @default.
• W4211072043 hasConceptScore W4211072043C204787440 @default.
• W4211072043 hasConceptScore W4211072043C22885893 @default.
• W4211072043 hasConceptScore W4211072043C2775859210 @default.
• W4211072043 hasConceptScore W4211072043C2776961477 @default.
• W4211072043 hasConceptScore W4211072043C2778616617 @default.
• W4211072043 hasConceptScore W4211072043C2778938600 @default.
• W4211072043 hasConceptScore W4211072043C2778941218 @default.

• next