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• W4211083132 abstract "Purine nucleoside analogs are a new class of drugs with activity against nondividing lymphocytes; thus, they should play a major role in the treatment of low-grade lymphoid malignancies.These drugs have been shown to have strong effect in DNA systhesis on actively dividing cells, through interference with DNA polymerases and ribonucleotide reductase, and for some of them through inhibition of DNA primase and DNA ligase. However, the cell cycle kinetics of low-grade lymphocytic lymphomas is characterized by the presence of very lowgrowth fractions. Hence, the action of these drugs in slowly progressing lymphoid malignancies cannot be accounted for by the same mechanism observed in actively proliferating tumors and needs to be explained through activity against quiescent resting lymphocytes. Recent work has stressed the role of purine analogs in inducing programmed cell death of quiescent lymphocytes, which could be explained through the induction of accelerated DNA strand breaks. This process leads to consumption of NAD for poly(ADP-ribose) synthesis, which could induce critical depletion of adenosine-5′-triphosphate (ATP).In addition, as their action extends to normal resting lymphocytes, deleterious effects related to their immunosuppressive action are also observed, i.e., prolonged lymphopenia predominating in T cells and especially in the CD4 subset and an increased frequency of opportunistic infections. Nevertheless, beneficial effects of this immunosuppressive action have also been reported for 2-chlorodeoxyadenosine (2CDA) in the case of autoimmune hemolytic anemia associated with chronic lymphocytic leukemia (CLL). These last results could offer some promise for these drugs in the field of immunosuppression.To substantiate this possibility, a considerable amount of work needs to be carried out in order to better define the mechanisms of action of these drugs, as well as their potential activity on different immunological effectors. Also, studies in animal models of autoimmune disease should be undertaken." @default.
• W4211083132 created "2022-02-13" @default.
• W4211083132 creator A5029354704 @default.
• W4211083132 date "1997-01-01" @default.
• W4211083132 modified "2023-09-25" @default.
• W4211083132 title "Potential Immunological Action of Purine Nucleoside Analogs" @default.
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• W4211083132 doi "https://doi.org/10.1007/978-3-642-60377-8_58" @default.
• W4211083132 hasPublicationYear "1997" @default.
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