Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211083622> ?p ?o ?g. }
- W4211083622 endingPage "88" @default.
- W4211083622 startingPage "55" @default.
- W4211083622 abstract "Ribonucleases are small basic proteins that have shown remarkable antitumor activity linked to their ability to destroy RNA. Therefore, they are a second line of cancer chemotherapeutics as they are not genotoxic. This chapter summarizes the main biochemical characteristics of these enzymes and the key factors responsible for their cytotoxic mechanism. Some of them are shared by most cytotoxins, but each RNase has particular cancer cell killing abilities. The effects on the cell cycle and the induced apoptosis mechanism are cell dependent. The knowledge obtained from the cytotoxic mechanism of natural cytotoxic RNases has been used to artificially engineer more potent and selective RNA-degrading enzymes. These approaches are also described. The chapter ends with a brief description of the results of the clinical trials performed with RNases." @default.
- W4211083622 created "2022-02-13" @default.
- W4211083622 creator A5008133128 @default.
- W4211083622 creator A5060598513 @default.
- W4211083622 creator A5077381064 @default.
- W4211083622 date "2011-01-01" @default.
- W4211083622 modified "2023-10-13" @default.
- W4211083622 title "Antitumor Ribonucleases" @default.
- W4211083622 cites W126577839 @default.
- W4211083622 cites W1484821298 @default.
- W4211083622 cites W14871158 @default.
- W4211083622 cites W1502471552 @default.
- W4211083622 cites W1503068946 @default.
- W4211083622 cites W1522344193 @default.
- W4211083622 cites W1529657332 @default.
- W4211083622 cites W1552732056 @default.
- W4211083622 cites W1574547932 @default.
- W4211083622 cites W1582725155 @default.
- W4211083622 cites W1582780353 @default.
- W4211083622 cites W1586992809 @default.
- W4211083622 cites W1593168979 @default.
- W4211083622 cites W1602127350 @default.
- W4211083622 cites W1635116362 @default.
- W4211083622 cites W183590699 @default.
- W4211083622 cites W1963791835 @default.
- W4211083622 cites W1966547604 @default.
- W4211083622 cites W1968087477 @default.
- W4211083622 cites W1969396432 @default.
- W4211083622 cites W1969741427 @default.
- W4211083622 cites W1970830875 @default.
- W4211083622 cites W1972708630 @default.
- W4211083622 cites W1974030999 @default.
- W4211083622 cites W1974443507 @default.
- W4211083622 cites W1974649577 @default.
- W4211083622 cites W1975234110 @default.
- W4211083622 cites W1976586880 @default.
- W4211083622 cites W1976789622 @default.
- W4211083622 cites W1977070052 @default.
- W4211083622 cites W1978421603 @default.
- W4211083622 cites W1978613846 @default.
- W4211083622 cites W1979791954 @default.
- W4211083622 cites W1979970885 @default.
- W4211083622 cites W1980970173 @default.
- W4211083622 cites W1981116974 @default.
- W4211083622 cites W1982694914 @default.
- W4211083622 cites W1984430184 @default.
- W4211083622 cites W1984674703 @default.
- W4211083622 cites W1984719034 @default.
- W4211083622 cites W1985139909 @default.
- W4211083622 cites W1986657051 @default.
- W4211083622 cites W1986901650 @default.
- W4211083622 cites W1989618640 @default.
- W4211083622 cites W1990315508 @default.
- W4211083622 cites W1991269320 @default.
- W4211083622 cites W1995061040 @default.
- W4211083622 cites W1995622741 @default.
- W4211083622 cites W1995889983 @default.
- W4211083622 cites W1996530722 @default.
- W4211083622 cites W1998745985 @default.
- W4211083622 cites W1999967193 @default.
- W4211083622 cites W2000088388 @default.
- W4211083622 cites W2000868983 @default.
- W4211083622 cites W2001673237 @default.
- W4211083622 cites W2002947104 @default.
- W4211083622 cites W2003561973 @default.
- W4211083622 cites W2004252505 @default.
- W4211083622 cites W2007260332 @default.
- W4211083622 cites W2007949653 @default.
- W4211083622 cites W2008167113 @default.
- W4211083622 cites W2008292964 @default.
- W4211083622 cites W2011831437 @default.
- W4211083622 cites W2012074506 @default.
- W4211083622 cites W2012670921 @default.
- W4211083622 cites W2012803773 @default.
- W4211083622 cites W2014817855 @default.
- W4211083622 cites W2015221912 @default.
- W4211083622 cites W2015270644 @default.
- W4211083622 cites W2015301666 @default.
- W4211083622 cites W201661893 @default.
- W4211083622 cites W2017020250 @default.
- W4211083622 cites W2017987939 @default.
- W4211083622 cites W2018447261 @default.
- W4211083622 cites W2018548970 @default.
- W4211083622 cites W2020930514 @default.
- W4211083622 cites W2021420392 @default.
- W4211083622 cites W2023226098 @default.
- W4211083622 cites W2023717652 @default.
- W4211083622 cites W2023907298 @default.
- W4211083622 cites W2024042048 @default.
- W4211083622 cites W2025084140 @default.
- W4211083622 cites W2026895880 @default.
- W4211083622 cites W2027578903 @default.
- W4211083622 cites W2028889866 @default.
- W4211083622 cites W2029716029 @default.
- W4211083622 cites W2030836217 @default.
- W4211083622 cites W2030910935 @default.
- W4211083622 cites W2032498806 @default.
- W4211083622 cites W2033206993 @default.