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• W4211083722 abstract "Abstract Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1 in vitro, our previous work has elucidated that, in vivo, I-2 may act as a positive regulator of PP1. Here we show that I-2 and PP1γ, but not PP1α, positively regulate synaptic transmission in hippocampal neurons. Moreover, we demonstrated that I-2 enhances PP1γ interaction with its major synaptic scaffold, neurabin, by Förster resonance energy transfer (FRET)/Fluorescence lifetime imaging microscopy (FLIM) studies, while having a limited effect on PP1 autoinhibitory phosphorylation. Furthermore, our study indicates that the effect of I-2 on PP1 activity in vivo is dictated by I-2 threonine-72 phosphorylation. Our work thus demonstrates a molecular mechanism by which I-2 positively regulates PP1 function in synaptic transmission." @default.
• W4211083722 created "2022-02-13" @default.
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• W4211083722 date "2022-02-11" @default.
• W4211083722 modified "2023-10-16" @default.
• W4211083722 title "PP1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission" @default.
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• W4211083722 doi "https://doi.org/10.1101/2022.02.10.480004" @default.
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