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- W4211085168 abstract "Biomineralization is the process in which organisms use minerals to generate hard structures like teeth, skeletons and shells. Biomineralization is proposed to have evolved independently in different phyla through the co-option of pre-existing developmental programs. Comparing the gene regulatory networks (GRNs) that drive biomineralization in different species could illuminate the molecular evolution of biomineralization. Skeletogenesis in the sea urchin embryo was extensively studied and the underlying GRN shows high conservation within echinoderms, larval and adult skeletogenesis. The organic scaffold in which the calcite skeletal elements form in echinoderms is a tubular compartment generated by the syncytial skeletogenic cells. This is strictly different than the organic cartilaginous scaffold that vertebrates mineralize with hydroxyapatite to make their bones. Here I compare the GRNs that drive biomineralization and tubulogenesis in echinoderms and in vertebrates. The GRN that drives skeletogenesis in the sea urchin embryo shows little similarity to the GRN that drives bone formation and high resemblance to the GRN that drives vertebrates' vascular tubulogenesis. On the other hand, vertebrates' bone-GRNs show high similarity to the GRNs that operate in the cells that generate the cartilage-like tissues of basal chordate and invertebrates that do not produce mineralized tissue. These comparisons suggest that biomineralization in deuterostomes evolved through the phylum specific co-option of GRNs that control distinct organic scaffolds to mineralization." @default.
- W4211085168 created "2022-02-13" @default.
- W4211085168 creator A5066434689 @default.
- W4211085168 date "2022-02-09" @default.
- W4211085168 modified "2023-09-27" @default.
- W4211085168 title "The Evolution of Biomineralization through the Co-Option of Organic Scaffold Forming Networks" @default.
- W4211085168 cites W107238186 @default.
- W4211085168 cites W1543888160 @default.
- W4211085168 cites W1573702280 @default.
- W4211085168 cites W1574424832 @default.
- W4211085168 cites W1623388651 @default.
- W4211085168 cites W1628826454 @default.
- W4211085168 cites W1652062575 @default.
- W4211085168 cites W166807143 @default.
- W4211085168 cites W1855561161 @default.
- W4211085168 cites W1864542480 @default.
- W4211085168 cites W1927199813 @default.
- W4211085168 cites W1963631486 @default.
- W4211085168 cites W1964660213 @default.
- W4211085168 cites W1965698145 @default.
- W4211085168 cites W1965879814 @default.
- W4211085168 cites W1966443300 @default.
- W4211085168 cites W1966517214 @default.
- W4211085168 cites W1966733510 @default.
- W4211085168 cites W1968577867 @default.
- W4211085168 cites W1968892287 @default.
- W4211085168 cites W1970163774 @default.
- W4211085168 cites W1971038955 @default.
- W4211085168 cites W1971489811 @default.
- W4211085168 cites W1973500743 @default.
- W4211085168 cites W1974595472 @default.
- W4211085168 cites W1975880530 @default.
- W4211085168 cites W1979883063 @default.
- W4211085168 cites W1981448346 @default.
- W4211085168 cites W1985633018 @default.
- W4211085168 cites W1986192245 @default.
- W4211085168 cites W1987048516 @default.
- W4211085168 cites W1987532345 @default.
- W4211085168 cites W1989988485 @default.
- W4211085168 cites W1991921027 @default.
- W4211085168 cites W1997067977 @default.
- W4211085168 cites W1997117548 @default.
- W4211085168 cites W1998200666 @default.
- W4211085168 cites W2000380160 @default.
- W4211085168 cites W2002006586 @default.
- W4211085168 cites W2003988669 @default.
- W4211085168 cites W2005413325 @default.
- W4211085168 cites W2006438300 @default.
- W4211085168 cites W2007629877 @default.
- W4211085168 cites W2008004759 @default.
- W4211085168 cites W2009434462 @default.
- W4211085168 cites W2012830422 @default.
- W4211085168 cites W2014059173 @default.
- W4211085168 cites W2015612505 @default.
- W4211085168 cites W2015925048 @default.
- W4211085168 cites W2016137413 @default.
- W4211085168 cites W2016390309 @default.
- W4211085168 cites W2019564264 @default.
- W4211085168 cites W2019744993 @default.
- W4211085168 cites W2020926536 @default.
- W4211085168 cites W2021558293 @default.
- W4211085168 cites W2022363275 @default.
- W4211085168 cites W2026490565 @default.
- W4211085168 cites W2026811263 @default.
- W4211085168 cites W2027889138 @default.
- W4211085168 cites W2031766495 @default.
- W4211085168 cites W2032074345 @default.
- W4211085168 cites W2034875461 @default.
- W4211085168 cites W2034876799 @default.
- W4211085168 cites W2036563087 @default.
- W4211085168 cites W2037705563 @default.
- W4211085168 cites W2038552399 @default.
- W4211085168 cites W2040234201 @default.
- W4211085168 cites W2042745325 @default.
- W4211085168 cites W2042873407 @default.
- W4211085168 cites W2047470479 @default.
- W4211085168 cites W2047594868 @default.
- W4211085168 cites W2048381363 @default.
- W4211085168 cites W2049793604 @default.
- W4211085168 cites W2057898427 @default.
- W4211085168 cites W2058015990 @default.
- W4211085168 cites W2060399360 @default.
- W4211085168 cites W2060772343 @default.
- W4211085168 cites W2063115615 @default.
- W4211085168 cites W2064191413 @default.
- W4211085168 cites W2067611733 @default.
- W4211085168 cites W2068501871 @default.
- W4211085168 cites W2070771744 @default.
- W4211085168 cites W2071359561 @default.
- W4211085168 cites W2071680116 @default.
- W4211085168 cites W2071895646 @default.
- W4211085168 cites W2072190909 @default.
- W4211085168 cites W2073045469 @default.
- W4211085168 cites W2074196937 @default.
- W4211085168 cites W2075819331 @default.
- W4211085168 cites W2076958216 @default.
- W4211085168 cites W2077378806 @default.
- W4211085168 cites W2081129368 @default.