FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211085775> ?p ?o ?g. }

• W4211085775 endingPage "2970" @default.
• W4211085775 startingPage "2951" @default.
• W4211085775 abstract "Sepsis is a type of systemic inflammation response syndrome that leads to organ function disorders. Currently, there is no specific medicine for sepsis in clinical practice. Lipopolysaccharide (LPS) is an important endotoxin that causes sepsis. Here, we report an effective two-drug combination therapy to treat LPS-induced liver and kidney injury in endotoxic rats. Ulinastatin (UTI) and Thrombomodulin (TM) are biological macromolecules extracted from urine. In our study, combination therapy significantly improved LPS-induced liver and kidney pathological structure and functional injury, and significantly improved the survival rate of endotoxic rats. Results of TUNEL staining and Western blot showed that UTI combined with TM inhibited the excessive apoptosis of liver and kidney cells caused by LPS. The drug combination also promoted the proliferation of liver and kidney cells, reduced the levels of pro-inflammatory factors interleukin (IL)-6, IL-1β, tumor or necrosis factor (TNF)-α and nitric oxide, and down-regulated the expression of High Mobility Group Box 1 (HMGB1), Toll-like receptor (TLR) 4 and Nuclear Factor (NF)-κB phosphorylation to inhibit inflammation. In addition, the combination of UTI and TM also promoted the production of a variety of antioxidant enzymes in the tissues and inhibited the production of lipid peroxidation malondialdehyde (MDA) to enhance antioxidant defenses. Our experiments also proved that UTI combined with TM did not reduce the anticoagulant effect of TM. These results suggested that UTI combined with TM can improve endotoxin-induced liver and kidney damage and mortality by inhibiting liver and kidney cell apoptosis, promoting proliferation, and inhibiting inflammation and oxidative injury." @default.
• W4211085775 created "2022-02-13" @default.
• W4211085775 creator A5018817360 @default.
• W4211085775 creator A5051236456 @default.
• W4211085775 creator A5064502323 @default.
• W4211085775 creator A5064803348 @default.
• W4211085775 creator A5073366227 @default.
• W4211085775 date "2022-02-01" @default.
• W4211085775 modified "2023-10-01" @default.
• W4211085775 title "Combination therapy of Ulinastatin with Thrombomodulin alleviates endotoxin (LPS) - induced liver and kidney injury via inhibiting apoptosis, oxidative stress and HMGB1/TLR4/NF-κB pathway" @default.
• W4211085775 cites W1496242532 @default.
• W4211085775 cites W1895448607 @default.
• W4211085775 cites W1969175670 @default.
• W4211085775 cites W1972689229 @default.
• W4211085775 cites W1973193961 @default.
• W4211085775 cites W1989528047 @default.
• W4211085775 cites W1996531679 @default.
• W4211085775 cites W2008225318 @default.
• W4211085775 cites W2067700440 @default.
• W4211085775 cites W2081073452 @default.
• W4211085775 cites W2101717411 @default.
• W4211085775 cites W2103369781 @default.
• W4211085775 cites W2151311812 @default.
• W4211085775 cites W2221838025 @default.
• W4211085775 cites W2280404143 @default.
• W4211085775 cites W2287751418 @default.
• W4211085775 cites W2317298677 @default.
• W4211085775 cites W2321922729 @default.
• W4211085775 cites W2341032101 @default.
• W4211085775 cites W2465535949 @default.
• W4211085775 cites W2618865740 @default.
• W4211085775 cites W2766199515 @default.
• W4211085775 cites W2774868879 @default.
• W4211085775 cites W2787913827 @default.
• W4211085775 cites W2792282260 @default.
• W4211085775 cites W2801189544 @default.
• W4211085775 cites W2888399409 @default.
• W4211085775 cites W2894313510 @default.
• W4211085775 cites W2902425824 @default.
• W4211085775 cites W2907542289 @default.
• W4211085775 cites W2968342712 @default.
• W4211085775 cites W2972802116 @default.
• W4211085775 cites W2976280279 @default.
• W4211085775 cites W2998615612 @default.
• W4211085775 cites W3002387340 @default.
• W4211085775 cites W3002676016 @default.
• W4211085775 cites W3007705893 @default.
• W4211085775 cites W3012314530 @default.
• W4211085775 cites W3013753034 @default.
• W4211085775 cites W3021020110 @default.
• W4211085775 cites W3021330613 @default.
• W4211085775 cites W3045466690 @default.
• W4211085775 cites W3047324830 @default.
• W4211085775 cites W3095607342 @default.
• W4211085775 cites W3097029179 @default.
• W4211085775 cites W3164878008 @default.
• W4211085775 cites W3177135270 @default.
• W4211085775 cites W3184850338 @default.
• W4211085775 cites W3185552876 @default.
• W4211085775 cites W3197617226 @default.
• W4211085775 cites W3201009436 @default.
• W4211085775 cites W3203056933 @default.
• W4211085775 cites W3207184655 @default.
• W4211085775 cites W3210466035 @default.
• W4211085775 cites W3214299891 @default.
• W4211085775 cites W977652477 @default.
• W4211085775 cites W2048305745 @default.
• W4211085775 doi "https://doi.org/10.1080/21655979.2021.2024686" @default.
• W4211085775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35148668" @default.
• W4211085775 hasPublicationYear "2022" @default.
• W4211085775 type Work @default.
• W4211085775 citedByCount "9" @default.
• W4211085775 countsByYear W42110857752022 @default.
• W4211085775 countsByYear W42110857752023 @default.
• W4211085775 crossrefType "journal-article" @default.
• W4211085775 hasAuthorship W4211085775A5018817360 @default.
• W4211085775 hasAuthorship W4211085775A5051236456 @default.
• W4211085775 hasAuthorship W4211085775A5064502323 @default.
• W4211085775 hasAuthorship W4211085775A5064803348 @default.
• W4211085775 hasAuthorship W4211085775A5073366227 @default.
• W4211085775 hasBestOaLocation W42110857751 @default.
• W4211085775 hasConcept C126322002 @default.
• W4211085775 hasConcept C17991360 @default.
• W4211085775 hasConcept C201267052 @default.
• W4211085775 hasConcept C203014093 @default.
• W4211085775 hasConcept C2776070231 @default.
• W4211085775 hasConcept C2776151105 @default.
• W4211085775 hasConcept C2776914184 @default.
• W4211085775 hasConcept C2777292125 @default.
• W4211085775 hasConcept C2778384902 @default.
• W4211085775 hasConcept C2778401633 @default.
• W4211085775 hasConcept C2778754761 @default.
• W4211085775 hasConcept C2780091579 @default.
• W4211085775 hasConcept C2780472472 @default.
• W4211085775 hasConcept C2780545709 @default.
• W4211085775 hasConcept C2780835948 @default.
• W4211085775 hasConcept C2781246285 @default.
• W4211085775 hasConcept C71924100 @default.

• next