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- W4211090967 abstract "Abstract Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. IL-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers, and in the context of numerous infectious diseases. This short review will describe the basic biology of IL-18 and thereafter address its potential effector and regulatory role in several human disease states including autoimmunity and infection. IL-18, previously known as interferon-γ (IFN-γ)-inducing factor, was identified as an endotoxin-induced serum factor that stimulated IFN-γ production by murine splenocytes [1]. IL-18 was cloned from a murine liver cell cDNA library generated from animals primed with heat-killed Propionibacterium acnes and subsequently challenged with lipopolysaccharide [2]. Nucleotide sequencing of murine IL-18 predicted a precursor polypeptide of 192 amino acids lacking a conventional signal peptide and a mature protein of 157 amino acids. Subsequent cloning of human IL-18 cDNA revealed 65% homology with murine IL-18 [3] and showed that both contain n unusual leader sequence consisting of 35 amino acids at their N terminus." @default.
- W4211090967 created "2022-02-13" @default.
- W4211090967 creator A5011775014 @default.
- W4211090967 creator A5031269142 @default.
- W4211090967 creator A5032207760 @default.
- W4211090967 date "2003-02-01" @default.
- W4211090967 modified "2023-10-14" @default.
- W4211090967 title "Interleukin-18" @default.
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