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- W4211093028 endingPage "2264" @default.
- W4211093028 startingPage "2253" @default.
- W4211093028 abstract "Human schistosomiasis—or bilharzia—is a parasitic disease caused by trematode flukes of the genus Schistosoma. By conservative estimates, at least 230 million people worldwide are infected with Schistosoma spp. Adult schistosome worms colonise human blood vessels for years, successfully evading the immune system while excreting hundreds to thousands of eggs daily, which must either leave the body in excreta or become trapped in nearby tissues. Trapped eggs induce a distinct immune-mediated granulomatous response that causes local and systemic pathological effects ranging from anaemia, growth stunting, impaired cognition, and decreased physical fitness, to organ-specific effects such as severe hepatosplenism, periportal fibrosis with portal hypertension, and urogenital inflammation and scarring. At present, preventive public health measures in endemic regions consist of treatment once every 1 or 2 years with the isoquinolinone drug, praziquantel, to suppress morbidity. In some locations, elimination of transmission is now the goal; however, more sensitive diagnostics are needed in both the field and clinics, and integrated environmental and health-care management will be needed to ensure elimination." @default.
- W4211093028 created "2022-02-13" @default.
- W4211093028 creator A5025686943 @default.
- W4211093028 creator A5035110680 @default.
- W4211093028 creator A5040573284 @default.
- W4211093028 creator A5076715795 @default.
- W4211093028 date "2014-06-01" @default.
- W4211093028 modified "2023-10-16" @default.
- W4211093028 title "Human schistosomiasis" @default.
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