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- W4211093785 abstract "PDZ domains bind to the C-terminal peptide of other proteins with affinities ranging from mM to high nM. Understanding the basis for peptide specificity to PDZ domains could open possibilities to change the PDZ domain into a chelator of peptides as a potential treatment for Alzheimer’s disease. The knob-socket model was used to identify the amino acid residues critical for the affinity and specificity to PDZ domains. The PDZ domain structure comprises 5 β-strands and 2 α-helices connected by 6 coil/turn segments." @default.
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- W4211093785 date "2022-02-01" @default.
- W4211093785 modified "2023-10-14" @default.
- W4211093785 title "Designing a PDZ chelator for Alzheimer’s peptides based on the knob-socket model" @default.
- W4211093785 doi "https://doi.org/10.1016/j.bpj.2021.11.2481" @default.
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