Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211095964> ?p ?o ?g. }
- W4211095964 abstract "ABSTRACT During severe infections, Staphylococcus aureus moves from its colonising sites to blood and tissues, and is exposed to new selective pressures, thus potentially driving adaptive evolution. Previous studies have shown the key role of the agr locus in S. aureus pathoadaptation, however a more comprehensive characterisation of genetic signatures of bacterial adaptation may enable prediction of clinical outcomes and reveal new targets for treatment and prevention of these infections. Here, we measured adaptation using within-host evolution analysis of 2,590 S. aureus genomes from 396 independent episodes of infection. By capturing a comprehensive repertoire of single-nucleotide and structural genome variations, we found evidence of a distinctive evolutionary pattern within the infecting populations compared to colonising bacteria. These invasive strains had up to 20-fold enrichments for genome degradation signatures and displayed significantly convergent mutations in a distinctive set of genes, linked to antibiotic response and pathogenesis. In addition to agr -mediated adaptation we identified non-canonical, genome-wide significant loci including sucA - sucB and stp1 . The prevalence of adaptive changes increased with infection extent, emphasising the clinical significance of these signatures. These findings provide a high-resolution picture of the molecular changes when S. aureus transitions from colonisation to severe infection and may inform correlation of infection outcomes with adaptation signatures." @default.
- W4211095964 created "2022-02-13" @default.
- W4211095964 creator A5002105758 @default.
- W4211095964 creator A5010650328 @default.
- W4211095964 creator A5021345648 @default.
- W4211095964 creator A5023103534 @default.
- W4211095964 creator A5044322089 @default.
- W4211095964 creator A5051736895 @default.
- W4211095964 creator A5058500554 @default.
- W4211095964 creator A5066412351 @default.
- W4211095964 creator A5069492497 @default.
- W4211095964 creator A5074189743 @default.
- W4211095964 creator A5088404965 @default.
- W4211095964 creator A5091121859 @default.
- W4211095964 date "2022-02-12" @default.
- W4211095964 modified "2023-09-27" @default.
- W4211095964 title "Niche-specific genome degradation and convergent evolution shaping <i>Staphylococcus aureus</i> adaptation during severe infections" @default.
- W4211095964 cites W1878404532 @default.
- W4211095964 cites W1964206937 @default.
- W4211095964 cites W1964339096 @default.
- W4211095964 cites W1967134059 @default.
- W4211095964 cites W1973891716 @default.
- W4211095964 cites W1979150116 @default.
- W4211095964 cites W1995606284 @default.
- W4211095964 cites W2020962641 @default.
- W4211095964 cites W2034677156 @default.
- W4211095964 cites W2035618305 @default.
- W4211095964 cites W2052512286 @default.
- W4211095964 cites W2053464832 @default.
- W4211095964 cites W2077572900 @default.
- W4211095964 cites W2094189284 @default.
- W4211095964 cites W2095820657 @default.
- W4211095964 cites W2096093282 @default.
- W4211095964 cites W2098533519 @default.
- W4211095964 cites W2099098590 @default.
- W4211095964 cites W2099839947 @default.
- W4211095964 cites W2102619694 @default.
- W4211095964 cites W2111326608 @default.
- W4211095964 cites W2117918141 @default.
- W4211095964 cites W2120036293 @default.
- W4211095964 cites W2122928584 @default.
- W4211095964 cites W2139150940 @default.
- W4211095964 cites W2141041292 @default.
- W4211095964 cites W2141269839 @default.
- W4211095964 cites W2146587287 @default.
- W4211095964 cites W2148245119 @default.
- W4211095964 cites W2155819206 @default.
- W4211095964 cites W2161158059 @default.
- W4211095964 cites W2161542240 @default.
- W4211095964 cites W2165335121 @default.
- W4211095964 cites W2169200218 @default.
- W4211095964 cites W2171347180 @default.
- W4211095964 cites W2171835460 @default.
- W4211095964 cites W2273624252 @default.
- W4211095964 cites W2283757273 @default.
- W4211095964 cites W2322749552 @default.
- W4211095964 cites W2409702784 @default.
- W4211095964 cites W2440341397 @default.
- W4211095964 cites W2475885067 @default.
- W4211095964 cites W2542326685 @default.
- W4211095964 cites W2547755118 @default.
- W4211095964 cites W2551929191 @default.
- W4211095964 cites W2591806215 @default.
- W4211095964 cites W2608738563 @default.
- W4211095964 cites W2611387862 @default.
- W4211095964 cites W2757862367 @default.
- W4211095964 cites W2763715289 @default.
- W4211095964 cites W2770806876 @default.
- W4211095964 cites W2779599349 @default.
- W4211095964 cites W2789535952 @default.
- W4211095964 cites W2790176873 @default.
- W4211095964 cites W2790760775 @default.
- W4211095964 cites W2793570678 @default.
- W4211095964 cites W2799828084 @default.
- W4211095964 cites W2803099788 @default.
- W4211095964 cites W2809994582 @default.
- W4211095964 cites W2846601550 @default.
- W4211095964 cites W2883556263 @default.
- W4211095964 cites W2886437201 @default.
- W4211095964 cites W2895070588 @default.
- W4211095964 cites W2897261795 @default.
- W4211095964 cites W2909855698 @default.
- W4211095964 cites W2913009720 @default.
- W4211095964 cites W2913922580 @default.
- W4211095964 cites W2914290436 @default.
- W4211095964 cites W2937008344 @default.
- W4211095964 cites W2937595795 @default.
- W4211095964 cites W2949848068 @default.
- W4211095964 cites W2950015644 @default.
- W4211095964 cites W2950190620 @default.
- W4211095964 cites W2950675215 @default.
- W4211095964 cites W2950754424 @default.
- W4211095964 cites W2951188778 @default.
- W4211095964 cites W2955249862 @default.
- W4211095964 cites W2957015183 @default.
- W4211095964 cites W2958045860 @default.
- W4211095964 cites W2964483300 @default.
- W4211095964 cites W2967125766 @default.
- W4211095964 cites W2974261957 @default.
- W4211095964 cites W2981971213 @default.