FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211102745> ?p ?o ?g. }

• W4211102745 abstract "The bioavailability of drugs is often related to intestinal metabolism and transport mechanisms. In previous studies, pharmaceutical excipients were recognized as inert substances in clinical safety evaluations. However, a large number of studies have shown that pharmaceutical excipients regulate the metabolism and transport of drugs in the body and improve the bioavailability. The pharmaceutical excipient polyethylene glycol 400 (PEG400) as a good solubilizer and surfactant has the potential to improve the bioavailability of drugs. The combined action of UDP-glucuronosyltransferases (UGTs) and efflux transport proteins is responsible for the intestinal disposition and poor bioavailability of baicalein. Our aim is to study the effect of PEG400 on the absorption of baicalein on the Caco-2 monolayer, and confirm the interaction of PEG400 with UGTs (UGT1A8 and UGT1A9) and efflux transports. We initially found that baicalein in the Caco-2 monolayer would be metabolized into glucuronide conjugates BG and B6G under the action of UGT1A8 and UGT1A9 on the endoplasmic reticulum membrane, and then mainly excreted to different sides by acting of MRP and BCRP. The addition of PEG400 significantly accelerated the metabolism of B in Caco-2 cells and increased the penetration of BG and B6G. Furthermore, PEG400 also significantly decreased the efflux ratio of BG and B6G, which was the evidence of the interaction with the efflux transporters. In the in vitro intestinal microsome regeneration system, low concentration PEG400 decreased the Km value of UGT1A8 and UGT1A9 (key enzymes that mediate the production of BG and B6G); high concentration PEG400 enhanced the Vmax value of UGT1A8 and UGT1A9. In conclusion, our results determined that PEG400 interacted with some UGTs and efflux transporters, which were the main factors affecting the absorption of baicalein." @default.
• W4211102745 created "2022-02-13" @default.
• W4211102745 creator A5001091754 @default.
• W4211102745 creator A5015527357 @default.
• W4211102745 creator A5016726568 @default.
• W4211102745 creator A5044129691 @default.
• W4211102745 creator A5053204257 @default.
• W4211102745 creator A5055924995 @default.
• W4211102745 creator A5058796919 @default.
• W4211102745 creator A5086328096 @default.
• W4211102745 creator A5089820817 @default.
• W4211102745 date "2022-02-01" @default.
• W4211102745 modified "2023-10-18" @default.
• W4211102745 title "The pharmaceutical excipient PEG400 affect the absorption of baicalein in Caco‐2 monolayer model by interacting with UDP‐glucuronosyltransferases and efflux transport proteins" @default.
• W4211102745 cites W1964515781 @default.
• W4211102745 cites W1967722478 @default.
• W4211102745 cites W1972516058 @default.
• W4211102745 cites W1994470556 @default.
• W4211102745 cites W2000369238 @default.
• W4211102745 cites W2016623506 @default.
• W4211102745 cites W2041587333 @default.
• W4211102745 cites W2062013076 @default.
• W4211102745 cites W2063164500 @default.
• W4211102745 cites W2070840005 @default.
• W4211102745 cites W2111917930 @default.
• W4211102745 cites W2150687023 @default.
• W4211102745 cites W2165711991 @default.
• W4211102745 cites W2295763664 @default.
• W4211102745 cites W2399692757 @default.
• W4211102745 cites W2559869600 @default.
• W4211102745 cites W2593448862 @default.
• W4211102745 cites W2605368176 @default.
• W4211102745 cites W2605400647 @default.
• W4211102745 cites W2742772106 @default.
• W4211102745 cites W2790034349 @default.
• W4211102745 cites W2793649128 @default.
• W4211102745 cites W2896944105 @default.
• W4211102745 cites W2899285523 @default.
• W4211102745 cites W2911495828 @default.
• W4211102745 cites W2946720417 @default.
• W4211102745 cites W3004969477 @default.
• W4211102745 cites W3016876073 @default.
• W4211102745 cites W3035765591 @default.
• W4211102745 cites W3043956341 @default.
• W4211102745 cites W3116762006 @default.
• W4211102745 cites W4211102745 @default.
• W4211102745 doi "https://doi.org/10.1002/prp2.928" @default.
• W4211102745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35148019" @default.
• W4211102745 hasPublicationYear "2022" @default.
• W4211102745 type Work @default.
• W4211102745 citedByCount "4" @default.
• W4211102745 countsByYear W42111027452022 @default.
• W4211102745 countsByYear W42111027452023 @default.
• W4211102745 crossrefType "journal-article" @default.
• W4211102745 hasAuthorship W4211102745A5001091754 @default.
• W4211102745 hasAuthorship W4211102745A5015527357 @default.
• W4211102745 hasAuthorship W4211102745A5016726568 @default.
• W4211102745 hasAuthorship W4211102745A5044129691 @default.
• W4211102745 hasAuthorship W4211102745A5053204257 @default.
• W4211102745 hasAuthorship W4211102745A5055924995 @default.
• W4211102745 hasAuthorship W4211102745A5058796919 @default.
• W4211102745 hasAuthorship W4211102745A5086328096 @default.
• W4211102745 hasAuthorship W4211102745A5089820817 @default.
• W4211102745 hasBestOaLocation W42111027453 @default.
• W4211102745 hasConcept C112705442 @default.
• W4211102745 hasConcept C181389837 @default.
• W4211102745 hasConcept C185592680 @default.
• W4211102745 hasConcept C193176779 @default.
• W4211102745 hasConcept C200082930 @default.
• W4211102745 hasConcept C201253974 @default.
• W4211102745 hasConcept C202751555 @default.
• W4211102745 hasConcept C2777239854 @default.
• W4211102745 hasConcept C2781466915 @default.
• W4211102745 hasConcept C43617362 @default.
• W4211102745 hasConcept C55493867 @default.
• W4211102745 hasConcept C71924100 @default.
• W4211102745 hasConcept C98274493 @default.
• W4211102745 hasConceptScore W4211102745C112705442 @default.
• W4211102745 hasConceptScore W4211102745C181389837 @default.
• W4211102745 hasConceptScore W4211102745C185592680 @default.
• W4211102745 hasConceptScore W4211102745C193176779 @default.
• W4211102745 hasConceptScore W4211102745C200082930 @default.
• W4211102745 hasConceptScore W4211102745C201253974 @default.
• W4211102745 hasConceptScore W4211102745C202751555 @default.
• W4211102745 hasConceptScore W4211102745C2777239854 @default.
• W4211102745 hasConceptScore W4211102745C2781466915 @default.
• W4211102745 hasConceptScore W4211102745C43617362 @default.
• W4211102745 hasConceptScore W4211102745C55493867 @default.
• W4211102745 hasConceptScore W4211102745C71924100 @default.
• W4211102745 hasConceptScore W4211102745C98274493 @default.
• W4211102745 hasFunder F4320321001 @default.
• W4211102745 hasIssue "1" @default.
• W4211102745 hasLocation W42111027451 @default.
• W4211102745 hasLocation W42111027452 @default.
• W4211102745 hasLocation W42111027453 @default.
• W4211102745 hasLocation W42111027454 @default.
• W4211102745 hasOpenAccess W4211102745 @default.
• W4211102745 hasPrimaryLocation W42111027451 @default.
• W4211102745 hasRelatedWork W1970245702 @default.
• W4211102745 hasRelatedWork W2017772866 @default.

• next