Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211105405> ?p ?o ?g. }
- W4211105405 endingPage "1255" @default.
- W4211105405 startingPage "1245" @default.
- W4211105405 abstract "Hepatocellular carcinoma is the sixth most prevalent cancer and the third most frequent cause of cancer-related death. Patients with cirrhosis are at highest risk of developing this malignant disease, and ultrasonography every 6 months is recommended. Surveillance with ultrasonography allows diagnosis at early stages when the tumour might be curable by resection, liver transplantation, or ablation, and 5-year survival higher than 50% can be achieved. Patients with small solitary tumours and very well preserved liver function are the best candidates for surgical resection. Liver transplantation is most beneficial for individuals who are not good candidates for resection, especially those within Milano criteria (solitary tumour ≤5 cm and up to three nodules ≤3 cm). Donor shortage greatly limits its applicability. Percutaneous ablation is the most frequently used treatment but its effectiveness is limited by tumour size and localisation. In asymptomatic patients with multifocal disease without vascular invasion or extrahepatic spread not amenable to curative treatments, chemoembolisation can provide survival benefit. Findings of randomised trials of sorafenib have shown survival benefits for individuals with advanced hepatocellular carcinoma, suggesting that molecular-targeted therapies could be effective in this chemoresistant cancer. Research is active in the area of pathogenesis and treatment of hepatocellular carcinoma." @default.
- W4211105405 created "2022-02-13" @default.
- W4211105405 creator A5052975894 @default.
- W4211105405 creator A5067464504 @default.
- W4211105405 creator A5080019152 @default.
- W4211105405 date "2012-03-01" @default.
- W4211105405 modified "2023-10-18" @default.
- W4211105405 title "Hepatocellular carcinoma" @default.
- W4211105405 cites W1563869372 @default.
- W4211105405 cites W1670652180 @default.
- W4211105405 cites W1943649358 @default.
- W4211105405 cites W1964051982 @default.
- W4211105405 cites W1964672254 @default.
- W4211105405 cites W1969368041 @default.
- W4211105405 cites W1971837077 @default.
- W4211105405 cites W1972259367 @default.
- W4211105405 cites W1974154130 @default.
- W4211105405 cites W1975154077 @default.
- W4211105405 cites W1980603418 @default.
- W4211105405 cites W1981536905 @default.
- W4211105405 cites W1981983512 @default.
- W4211105405 cites W1981989535 @default.
- W4211105405 cites W1983154697 @default.
- W4211105405 cites W1988051941 @default.
- W4211105405 cites W1990073288 @default.
- W4211105405 cites W1990499032 @default.
- W4211105405 cites W1992886217 @default.
- W4211105405 cites W1992919208 @default.
- W4211105405 cites W1994193851 @default.
- W4211105405 cites W1995180061 @default.
- W4211105405 cites W1996109529 @default.
- W4211105405 cites W1998417832 @default.
- W4211105405 cites W1999867233 @default.
- W4211105405 cites W2000001318 @default.
- W4211105405 cites W2000249913 @default.
- W4211105405 cites W2007624969 @default.
- W4211105405 cites W2007764123 @default.
- W4211105405 cites W2009671859 @default.
- W4211105405 cites W2011791532 @default.
- W4211105405 cites W2020215421 @default.
- W4211105405 cites W2021299297 @default.
- W4211105405 cites W2022138851 @default.
- W4211105405 cites W2023250239 @default.
- W4211105405 cites W2025016366 @default.
- W4211105405 cites W2025890159 @default.
- W4211105405 cites W2027380378 @default.
- W4211105405 cites W2029879555 @default.
- W4211105405 cites W2032284698 @default.
- W4211105405 cites W2034320803 @default.
- W4211105405 cites W2038280383 @default.
- W4211105405 cites W2039281320 @default.
- W4211105405 cites W2039677460 @default.
- W4211105405 cites W2040799770 @default.
- W4211105405 cites W2042158802 @default.
- W4211105405 cites W2043090634 @default.
- W4211105405 cites W2043162780 @default.
- W4211105405 cites W2043986434 @default.
- W4211105405 cites W2046257690 @default.
- W4211105405 cites W2049802695 @default.
- W4211105405 cites W2049811920 @default.
- W4211105405 cites W2051193106 @default.
- W4211105405 cites W2052552898 @default.
- W4211105405 cites W2057378223 @default.
- W4211105405 cites W2057977939 @default.
- W4211105405 cites W2060050131 @default.
- W4211105405 cites W2060123467 @default.
- W4211105405 cites W2061542009 @default.
- W4211105405 cites W2065543285 @default.
- W4211105405 cites W2065589690 @default.
- W4211105405 cites W2066593706 @default.
- W4211105405 cites W2067691895 @default.
- W4211105405 cites W2069243984 @default.
- W4211105405 cites W2070080743 @default.
- W4211105405 cites W2070912978 @default.
- W4211105405 cites W2071282740 @default.
- W4211105405 cites W2072554662 @default.
- W4211105405 cites W2079647133 @default.
- W4211105405 cites W2080782096 @default.
- W4211105405 cites W2084952307 @default.
- W4211105405 cites W2085245422 @default.
- W4211105405 cites W2088131723 @default.
- W4211105405 cites W2088305891 @default.
- W4211105405 cites W2088629624 @default.
- W4211105405 cites W2089114108 @default.
- W4211105405 cites W2089957623 @default.
- W4211105405 cites W2090439540 @default.
- W4211105405 cites W2092759077 @default.
- W4211105405 cites W2094873643 @default.
- W4211105405 cites W2096808350 @default.
- W4211105405 cites W2102272818 @default.
- W4211105405 cites W2102786318 @default.
- W4211105405 cites W2104389844 @default.
- W4211105405 cites W2108346479 @default.
- W4211105405 cites W2111298327 @default.
- W4211105405 cites W2115253754 @default.
- W4211105405 cites W2118698732 @default.
- W4211105405 cites W2121984426 @default.
- W4211105405 cites W2125763116 @default.