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• W4211105809 endingPage "12" @default.
• W4211105809 startingPage "1" @default.
• W4211105809 abstract "Abstract Initiation of transcription is a complex process, requiring melting of the DNA duplex at a sequence‐defined location, de novo synthesis of an initial dinucleotide, polymerization/growth from that dinucleotide to a larger oligonucleotide in an extended RNA‐DNA hybrid, displacement and threading of the 5′ end of the RNA into an exit channel, and release of the initial promoter contacts. These events are necessarily driven energetically by growth of the RNA‐DNA hybrid. It has long been expected and is now becoming structurally clear that stress inherent in this transformation leads to instability during this phase and is a source of the abortive release of short RNA products that is characteristic of RNA polymerases. That apparently unrelated single and multisubunit RNA polymerases share extensive mechanistic (but not structural) homology, likely reflects the demands of the process." @default.
• W4211105809 created "2022-02-13" @default.
• W4211105809 creator A5055145940 @default.
• W4211105809 creator A5085256219 @default.
• W4211105809 date "2008-05-15" @default.
• W4211105809 modified "2023-10-10" @default.
• W4211105809 title "Transcription: Initiation" @default.
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