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- W4211112078 abstract "Abstract Background The apolipoprotein E ( APOE ) ε4 allele confers higher risk of neurodegeneration and Alzheimer's disease (AD), but differs by race/ethnicity. We examined this association in American Indians. Methods The Strong Heart Study is a population‐based cohort of American Indians who were 64 to 95 years of age in 2010 to 2013. APOE ε4 status, brain imaging, and neuropsychological testing was collected in N = 811 individuals. Summary statistics, graphics, and generalized linear regressions—adjusted for sociodemographics, clinical features, and intracranial volume with bootstrap variance estimator—compared APOE ε4 carriers with non‐carriers. Results APOE ε4 carriers comprised 22% of the population (0.7% homozygotes). Participants were mean 73 years, 67% female, and 54% had some college education. The majority were obese (>50%), hypertensive (>80%), and diabetic (>50%). Neither imaging findings nor multidomain cognitive testing showed any substantive differences between APOE ε4 carriers and non‐carriers. Conclusion We found no evidence of neurodegenerative risk from APOE ε4 in American Indians. Additional studies are needed to examine potential protective features." @default.
- W4211112078 created "2022-02-13" @default.
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- W4211112078 date "2022-02-10" @default.
- W4211112078 modified "2023-10-15" @default.
- W4211112078 title "<i>APOE</i> genotype, hippocampus, and cognitive markers of Alzheimer's disease in American Indians: Data from the Strong Heart Study" @default.
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- W4211112078 doi "https://doi.org/10.1002/alz.12573" @default.
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