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• W4211113485 abstract "Self-stigma is common in patients with Parkinson's disease (PD) and may lead to social isolation and delayed search for medical help. We conducted a 3-year prospective longitudinal study to investigate the development and evolution of self-stigma in patients with early stage PD and to explore the associated and predictive factors of self-stigma in PD.A total of 224 patients with early stage PD (disease duration <3 years) were enrolled at baseline and followed up annually for 3 consecutive years. Self-stigma was assessed by the stigma subscale of the Parkinson's Disease Questionnaire (items 23-26). The generalized estimating equation model was used to investigate the associated factors of self-stigma over 3 years, and the binary logistic model was used to explore the predictors of self-stigma in patients with PD without self-stigma at baseline.The prevalence of self-stigma decreased from 58.0% at baseline to 49.2% after 3 years. The Hamilton Depression Rating Scale (HDRS) score was the only associated factor [B: 0.160 (1.106-0.214), P < 0.001] of self-stigma over 3 years and the only predictor [OR: 1.252 (1.044-1.502), P = 0.015] of the onset of self-stigma.Self-stigma is very common in PD, but its prevalence tends to decrease as the disease progresses. Depression was the only associated and predictive factor of self-stigma in PD and could be an effective target of alleviating self-stigma." @default.
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• W4211113485 date "2022-02-11" @default.
• W4211113485 modified "2023-10-15" @default.
• W4211113485 title "Self-Stigma in Parkinson's Disease: A 3-Year Prospective Cohort Study" @default.
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• W4211113485 doi "https://doi.org/10.3389/fnagi.2022.790897" @default.
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