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- W4211118647 abstract "Mechanobiology describes how the physical forces and mechanical properties of biological material contribute to physiology and disease. Typically, these approaches are limited single-molecule methods, which restricts their availability. To address this need, a microplate assay was developed that enables mechanical manipulation while performing standard biochemical assays. This is achieved using magnets incorporated into a microplate lid to create multiple magnetic tweezers. In this format, force is exerted across biomolecules connected to paramagnetic beads, equivalent to a typical magnetic tweezer. The study demonstrates the application of this tool with FRET-based assays to monitor protein conformations. However, this approach is widely applicable to different biological systems ranging from measuring enzymatic activity through to the activation of signaling pathways in live cells." @default.
- W4211118647 created "2022-02-13" @default.
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- W4211118647 date "2022-02-09" @default.
- W4211118647 modified "2023-10-03" @default.
- W4211118647 title "Magnetic Tweezers in a Microplate Format" @default.
- W4211118647 doi "https://doi.org/10.3791/62994" @default.
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