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- W4211124920 endingPage "604" @default.
- W4211124920 startingPage "604" @default.
- W4211124920 abstract "Heart failure is a leading cause of death that develops subsequent to deleterious hypertrophic cardiac remodelling. MAPK pathways play a key role in coordinating the induction of gene expression during hypertrophy. Induction of the immediate early gene (IEG) response including activator protein 1 (AP-1) complex factors is a necessary and early event in this process. How MAPK and IEG expression are coupled during cardiac hypertrophy is not resolved. Here, in vitro, in rodent models and in human samples, we demonstrate that MAPK-stimulated IEG induction depends on the mitogen and stress-activated protein kinase (MSK) and its phosphorylation of histone H3 at serine 28 (pH3S28). pH3S28 in IEG promoters in turn recruits Brg1, a BAF60 ATP-dependent chromatin remodelling complex component, initiating gene expression. Without MSK activity and IEG induction, the hypertrophic response is suppressed. These studies provide new mechanistic insights into the role of MAPK pathways in signalling to the epigenome and regulation of gene expression during cardiac hypertrophy." @default.
- W4211124920 created "2022-02-13" @default.
- W4211124920 creator A5004459131 @default.
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- W4211124920 creator A5072723519 @default.
- W4211124920 creator A5077073440 @default.
- W4211124920 creator A5086935273 @default.
- W4211124920 date "2022-02-09" @default.
- W4211124920 modified "2023-10-15" @default.
- W4211124920 title "MSK-Mediated Phosphorylation of Histone H3 Ser28 Couples MAPK Signalling with Early Gene Induction and Cardiac Hypertrophy" @default.
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