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- W4211128413 abstract "Topiramate is a second-generation antiepileptic drug (AED) that exerts antiepileptic activities by a combination of mechanisms of action, resulting in a relatively broad-spectrum efficacy in a variety of seizure types (focal and generalized), epilepsy syndromes and epilepsies associated with different aetiologies. Topiramate produces its anticonvulsant effects through inhibition of voltage-sensitive sodium and calcium channels, enhancement of γ-aminobutyric acid (GABA)-mediated activity and inhibition of kainate and AMPA (a-amino-3-hydroxy-5-methylisoxazole-4- proprionic acid)-type glutamate receptors. Within the normal dosing range, topiramate shows linear pharmacokinetics. An overview of studies that assessed the relationship between serum topiramate concentrations and clinical response concluded that patients receiving therapeutic doses usually have levels in the range of 5-20 mg/L. The pivotal adjunctive therapy trials have demonstrated a reduction in frequency of seizures by at least 50% in 35-50% of subjects. It is a useful antiepileptic drug with relatively broad-spectrum efficacy." @default.
- W4211128413 created "2022-02-13" @default.
- W4211128413 creator A5064704949 @default.
- W4211128413 creator A5082065118 @default.
- W4211128413 date "2015-10-02" @default.
- W4211128413 modified "2023-10-18" @default.
- W4211128413 title "Topiramate" @default.
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