FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211132718> ?p ?o ?g. }

• W4211132718 abstract "Acute lung injury (ALI) is a common complication of critical illness that could frequently lead to acute respiratory distress syndrome and other serious clinical consequences. Sepsis is one of the major and most common inducements among all causes of ALI. Due to its high incidence and mortality rate and also the complexity in treatment, sepsis-related ALI has become an urgent clinical problem waiting to be solved effectively. At present, only the protective ventilation strategy, restrictive fluid management, and antibiotics application are measures that can improve the prognosis with evidence-based medical proof. No pharmacological treatment is currently available to protect or significantly reverse the prognosis. Seeking for effective interventions measures for sepsis-related ALI is one of the most necessitous research directions. In this research, a conspicuous discovery of treatment-related translational use for a 4-benzene-indol derivative was elaborated by screening a large number of chemical compounds. The results showed that 4-benzene-indol derivative could not only suppress the activation of NLRP3 inflammasome both in vitro and alleviate LPS-induced ALI in vivo but also suppress the NLRP3 inflammasome in human myeloid leukemia mononuclear cells (THP-1) cell lines. Mechanistically, 1,2-diol blocks the NLRP3 inflammasome activation by disrupting NLRP3-NEK7 interaction and the subsequent NLRP3 inflammasome assembly and activation. To summarize, this research indicated that the newly-discovered 4-benzene-indol derivative targets NLRP3 inflammasome signaling, which consequently alleviates sepsis-related ALI. Collectively, the 4-benzene-indol derivative may serve as a potential therapeutic drug and NLRP3 inflammasome signaling would be a novel pharmaceutical target for clinical treatment of sepsis-related ALI." @default.
• W4211132718 created "2022-02-13" @default.
• W4211132718 creator A5000839558 @default.
• W4211132718 creator A5010325699 @default.
• W4211132718 creator A5022172597 @default.
• W4211132718 creator A5032469771 @default.
• W4211132718 creator A5044544424 @default.
• W4211132718 creator A5063862218 @default.
• W4211132718 creator A5078202447 @default.
• W4211132718 creator A5078423602 @default.
• W4211132718 creator A5081451261 @default.
• W4211132718 date "2022-02-10" @default.
• W4211132718 modified "2023-09-27" @default.
• W4211132718 title "A 4-Benzene-Indol Derivative Alleviates LPS-Induced Acute Lung Injury Through Inhibiting the NLRP3 Inflammasome" @default.
• W4211132718 cites W1803784511 @default.
• W4211132718 cites W1928848518 @default.
• W4211132718 cites W197847626 @default.
• W4211132718 cites W1987293334 @default.
• W4211132718 cites W2008780228 @default.
• W4211132718 cites W2028457710 @default.
• W4211132718 cites W2052395914 @default.
• W4211132718 cites W2054780491 @default.
• W4211132718 cites W2063375692 @default.
• W4211132718 cites W2088016032 @default.
• W4211132718 cites W2088164523 @default.
• W4211132718 cites W2138056062 @default.
• W4211132718 cites W2148021308 @default.
• W4211132718 cites W2168803832 @default.
• W4211132718 cites W2275708639 @default.
• W4211132718 cites W2317488575 @default.
• W4211132718 cites W2407405722 @default.
• W4211132718 cites W2509680513 @default.
• W4211132718 cites W2522054313 @default.
• W4211132718 cites W2620241325 @default.
• W4211132718 cites W2739648684 @default.
• W4211132718 cites W2800130866 @default.
• W4211132718 cites W2803964164 @default.
• W4211132718 cites W2911549495 @default.
• W4211132718 cites W2923716180 @default.
• W4211132718 cites W2970945400 @default.
• W4211132718 cites W2988152617 @default.
• W4211132718 cites W3010892573 @default.
• W4211132718 cites W3033829306 @default.
• W4211132718 cites W3036294205 @default.
• W4211132718 cites W3156468205 @default.
• W4211132718 cites W3211959642 @default.
• W4211132718 cites W4211250103 @default.
• W4211132718 cites W4229785675 @default.
• W4211132718 doi "https://doi.org/10.3389/fimmu.2022.812164" @default.
• W4211132718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35222388" @default.
• W4211132718 hasPublicationYear "2022" @default.
• W4211132718 type Work @default.
• W4211132718 citedByCount "5" @default.
• W4211132718 countsByYear W42111327182022 @default.
• W4211132718 countsByYear W42111327182023 @default.
• W4211132718 crossrefType "journal-article" @default.
• W4211132718 hasAuthorship W4211132718A5000839558 @default.
• W4211132718 hasAuthorship W4211132718A5010325699 @default.
• W4211132718 hasAuthorship W4211132718A5022172597 @default.
• W4211132718 hasAuthorship W4211132718A5032469771 @default.
• W4211132718 hasAuthorship W4211132718A5044544424 @default.
• W4211132718 hasAuthorship W4211132718A5063862218 @default.
• W4211132718 hasAuthorship W4211132718A5078202447 @default.
• W4211132718 hasAuthorship W4211132718A5078423602 @default.
• W4211132718 hasAuthorship W4211132718A5081451261 @default.
• W4211132718 hasBestOaLocation W42111327181 @default.
• W4211132718 hasConcept C203014093 @default.
• W4211132718 hasConcept C2776914184 @default.
• W4211132718 hasConcept C2777209026 @default.
• W4211132718 hasConcept C2778384902 @default.
• W4211132718 hasConcept C71924100 @default.
• W4211132718 hasConcept C98274493 @default.
• W4211132718 hasConceptScore W4211132718C203014093 @default.
• W4211132718 hasConceptScore W4211132718C2776914184 @default.
• W4211132718 hasConceptScore W4211132718C2777209026 @default.
• W4211132718 hasConceptScore W4211132718C2778384902 @default.
• W4211132718 hasConceptScore W4211132718C71924100 @default.
• W4211132718 hasConceptScore W4211132718C98274493 @default.
• W4211132718 hasLocation W42111327181 @default.
• W4211132718 hasLocation W42111327182 @default.
• W4211132718 hasLocation W42111327183 @default.
• W4211132718 hasLocation W42111327184 @default.
• W4211132718 hasOpenAccess W4211132718 @default.
• W4211132718 hasPrimaryLocation W42111327181 @default.
• W4211132718 hasRelatedWork W2137121438 @default.
• W4211132718 hasRelatedWork W2408010109 @default.
• W4211132718 hasRelatedWork W2605001341 @default.
• W4211132718 hasRelatedWork W3005624538 @default.
• W4211132718 hasRelatedWork W3023793823 @default.
• W4211132718 hasRelatedWork W3107698508 @default.
• W4211132718 hasRelatedWork W4213129797 @default.
• W4211132718 hasRelatedWork W4281567326 @default.
• W4211132718 hasRelatedWork W4283696366 @default.
• W4211132718 hasRelatedWork W4317598154 @default.
• W4211132718 hasVolume "13" @default.
• W4211132718 isParatext "false" @default.
• W4211132718 isRetracted "false" @default.
• W4211132718 workType "article" @default.