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• W4211133222 abstract "This chapter discusses nephrotoxic effects of cyclosporine in humans and animal systems. Development of animal models of cyclosporine nephrotoxicity is particularly important because the clinical settings in which this agent is used are often very complicated, making it difficult to define directly the pathology and pathophysiology of renal injury produced by the drug. Moreover, certain types of studies are not possible in human patients because of the technical or ethical considerations or both, making studies in experimental models even more critical. Morphologically, cyclosporine nephrotoxicity appears fundamentally different from the nephrotoxicity of other drugs, but there remains a significant problem differentiating cyclosporine nephrotoxicity from acute rejection. The chapter discusses studies on the potentiation of cyclosporine nephrotoxicity by other factors such as ischemia or concurrent administration of other drugs and the importance of hepatic metabolism of cyclosporine in the production of toxic renal effects. It presents four discrete syndromes of clinically significant renal dysfunction caused by cyclosporine in the native or grafted kidney: (1) acute reversible renal insufficiency, (2) delayed renal allograft function, (3) acute vasculopathy, and (4) chronic nephropathy with interstitial fibrosis. These four types of nephrotoxicity are probably related, but it is not clear that episodes of acute reversible dysfunction increase the likelihood of chronic toxicity. Further experimental studies are clearly needed to improve the understanding of clinical nephrotoxicity and to devise ways of avoiding or lessening it. The acute vasculopathy may manifest itself within one hour after transplantation and appears frequently to be a self-limited process." @default.
• W4211133222 created "2022-02-13" @default.
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• W4211133222 date "1988-01-01" @default.
• W4211133222 modified "2023-09-29" @default.
• W4211133222 title "Cyclosporine Nephrotoxicity" @default.
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• W4211133222 doi "https://doi.org/10.1016/b978-0-12-364930-0.50007-5" @default.
• W4211133222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3061960" @default.
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