Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211134326> ?p ?o ?g. }
- W4211134326 endingPage "14" @default.
- W4211134326 startingPage "5" @default.
- W4211134326 abstract "The clinical syndrome of congestive heart failure remains a therapeutic dilemma and challenge for the physician in 1992. This is a disease process that appears to be increasing in frequency and continues to carry an unacceptably high mortality rate. For years it has been well recognized that the combination of digoxin, Lasix and vasodilator therapy improved symptoms in these patients and decreased hospitalization, but did not increase survival. It was not until 1986 that the combination of digoxin, Lasix, Isordil, and hydralazine was shown to increase survival. Further significant improvement in quality of life and survival has recently been established in three large clinical trials, and it is now safe to say that the standard of care for symptomatic congestive heart failure in 1992 is digoxin, furosemide, and an ACE inhibitor, with the survival trials favoring the ACE inhibitor enalapril. The IV inotropic drug dobutamine remains the mainstay of pharmacological therapy for the treatment of severely refractory heart failure. Unfortunately, the phosphodiesterase inhibitors—amrinone, milrinone, and enoximone—have demonstrated unacceptable clinical side effects and have been withdrawn from further clinical study. In spite of these promising developments, the mortality and morbidity of congestive heart failure remains unacceptably high, and continued investigation in the new fields of pharmacology and the pathophysiology of congestive heart failure still must be aggressively pursued." @default.
- W4211134326 created "2022-02-13" @default.
- W4211134326 creator A5025835472 @default.
- W4211134326 creator A5075375896 @default.
- W4211134326 date "1993-01-01" @default.
- W4211134326 modified "2023-09-25" @default.
- W4211134326 title "Inotropic therapy of the failing myocardium" @default.
- W4211134326 cites W1577502712 @default.
- W4211134326 cites W1964933218 @default.
- W4211134326 cites W1965735440 @default.
- W4211134326 cites W1968673950 @default.
- W4211134326 cites W1968702004 @default.
- W4211134326 cites W1969910718 @default.
- W4211134326 cites W1970159829 @default.
- W4211134326 cites W1970205478 @default.
- W4211134326 cites W1973359885 @default.
- W4211134326 cites W1974703478 @default.
- W4211134326 cites W1980258822 @default.
- W4211134326 cites W1980966827 @default.
- W4211134326 cites W1985942759 @default.
- W4211134326 cites W1987949657 @default.
- W4211134326 cites W1987992525 @default.
- W4211134326 cites W1989524686 @default.
- W4211134326 cites W1991252116 @default.
- W4211134326 cites W1991638901 @default.
- W4211134326 cites W1991715987 @default.
- W4211134326 cites W1996972993 @default.
- W4211134326 cites W1997475700 @default.
- W4211134326 cites W1999117580 @default.
- W4211134326 cites W2010094172 @default.
- W4211134326 cites W2011205516 @default.
- W4211134326 cites W2017380495 @default.
- W4211134326 cites W2025570168 @default.
- W4211134326 cites W2025656770 @default.
- W4211134326 cites W2027858961 @default.
- W4211134326 cites W2027938050 @default.
- W4211134326 cites W2029942224 @default.
- W4211134326 cites W2031318351 @default.
- W4211134326 cites W2033256644 @default.
- W4211134326 cites W2034052668 @default.
- W4211134326 cites W2035377210 @default.
- W4211134326 cites W2036116724 @default.
- W4211134326 cites W2036847432 @default.
- W4211134326 cites W2039801116 @default.
- W4211134326 cites W2042491407 @default.
- W4211134326 cites W2043752640 @default.
- W4211134326 cites W2044536933 @default.
- W4211134326 cites W2045202330 @default.
- W4211134326 cites W2045657917 @default.
- W4211134326 cites W2046383587 @default.
- W4211134326 cites W2048592279 @default.
- W4211134326 cites W2050034675 @default.
- W4211134326 cites W2050715789 @default.
- W4211134326 cites W2051487521 @default.
- W4211134326 cites W2055902440 @default.
- W4211134326 cites W2056094016 @default.
- W4211134326 cites W2056460863 @default.
- W4211134326 cites W2057378891 @default.
- W4211134326 cites W2057705500 @default.
- W4211134326 cites W2059560933 @default.
- W4211134326 cites W2059697928 @default.
- W4211134326 cites W2060829078 @default.
- W4211134326 cites W2066378462 @default.
- W4211134326 cites W2068189586 @default.
- W4211134326 cites W2078020030 @default.
- W4211134326 cites W2079993971 @default.
- W4211134326 cites W2081463304 @default.
- W4211134326 cites W2083207272 @default.
- W4211134326 cites W2083633952 @default.
- W4211134326 cites W2084462174 @default.
- W4211134326 cites W2085468443 @default.
- W4211134326 cites W2086158842 @default.
- W4211134326 cites W2090121413 @default.
- W4211134326 cites W2090393028 @default.
- W4211134326 cites W2091091328 @default.
- W4211134326 cites W2092128668 @default.
- W4211134326 cites W2098834360 @default.
- W4211134326 cites W2110803752 @default.
- W4211134326 cites W2110889457 @default.
- W4211134326 cites W2115887355 @default.
- W4211134326 cites W2117253018 @default.
- W4211134326 cites W2117834436 @default.
- W4211134326 cites W2126774767 @default.
- W4211134326 cites W2133041246 @default.
- W4211134326 cites W2140128769 @default.
- W4211134326 cites W2141080532 @default.
- W4211134326 cites W2157973908 @default.
- W4211134326 cites W2312292690 @default.
- W4211134326 cites W2319534362 @default.
- W4211134326 cites W2336602334 @default.
- W4211134326 cites W2336694219 @default.
- W4211134326 cites W2337580091 @default.
- W4211134326 cites W2585382523 @default.
- W4211134326 cites W3149576662 @default.
- W4211134326 cites W4245244523 @default.
- W4211134326 cites W4246720753 @default.
- W4211134326 cites W4302070907 @default.
- W4211134326 cites W4362071483 @default.