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- W4211136136 abstract "The E3 ubiquitin ligase adaptor SPOP plays a key role in the regulation of numerous transcription factors, cell cycle regulators, and other proteins. SPOP binds to target substrate proteins through its substrate-recognition MATH domain, and recruits ubiquitin ligases by its tandem dimerization domains. In particular, SPOP favors binding within intrinsically disordered regions (IDRs) of substrates; such IDRs often contain multiple SPOP-binding motifs, which enables high-affinity binding and processive ubiquitination activity through multivalent interactions." @default.
- W4211136136 created "2022-02-13" @default.
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- W4211136136 date "2022-02-01" @default.
- W4211136136 modified "2023-09-30" @default.
- W4211136136 title "Determinants of E3 ligase adaptor SPOP binding to intrinsically disordered substrates" @default.
- W4211136136 doi "https://doi.org/10.1016/j.bpj.2021.11.2517" @default.
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