FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4211137142> ?p ?o ?g. }

• W4211137142 endingPage "505" @default.
• W4211137142 startingPage "499" @default.
• W4211137142 abstract "This research aimed to investigate how the relationship between counter ion and diacerein (DCN) exerts an effect on the skin penetration of DCN ion-pair compounds. After the ion-pair compounds were formed by DCN and organic amines with different functional groups, the hydrogen bond of these compounds was confirmed by Fourier-transform infrared (FTIR) spectroscopy and molecular docking. The skin of porcine ears was employed to conduct the in vitro skin penetration, DCN - triethanolamine was the most potential candidate with the Q24h of 7.89 ± 0.38 µg/cm2 among organic amines with different functional groups. Whereas among the homologous fatty amine, the most permeable compound was DCN - lauryl amine with the Q24h of 11.28 ± 0.48 µg/cm2. Molecular simulation was employed to explore the relationship between counter ion and DCN. It was revealed by the bind energy curve that DCN had the strongest compatibility with triethanolamine among organic amines and laurylamine (N12) among fatty amines. It was amazingly found that the in vitro permeation fluxes of DCN ion-pair compounds would increase with enhancing the compatibility of counter ion and DCN. These findings broadened our understanding of how the relationship between drug and counter ion affects the skin penetration of ion-pair compounds." @default.
• W4211137142 created "2022-02-13" @default.
• W4211137142 creator A5011241874 @default.
• W4211137142 creator A5011584029 @default.
• W4211137142 creator A5012313693 @default.
• W4211137142 creator A5033638005 @default.
• W4211137142 creator A5033785543 @default.
• W4211137142 creator A5056876818 @default.
• W4211137142 creator A5076606717 @default.
• W4211137142 date "2022-02-11" @default.
• W4211137142 modified "2023-09-29" @default.
• W4211137142 title "Ion-pair compounds of diacerein for enhancing skin permeability in vitro: the compatibility–permeability relationship of counter ion and diacerein" @default.
• W4211137142 cites W1170555510 @default.
• W4211137142 cites W1966331032 @default.
• W4211137142 cites W1972518132 @default.
• W4211137142 cites W1973415762 @default.
• W4211137142 cites W1974888608 @default.
• W4211137142 cites W1976448838 @default.
• W4211137142 cites W1994829140 @default.
• W4211137142 cites W2009957165 @default.
• W4211137142 cites W2017291275 @default.
• W4211137142 cites W2023187823 @default.
• W4211137142 cites W2037729216 @default.
• W4211137142 cites W2055520027 @default.
• W4211137142 cites W2094249166 @default.
• W4211137142 cites W2096524229 @default.
• W4211137142 cites W2102864371 @default.
• W4211137142 cites W2138178106 @default.
• W4211137142 cites W2140356751 @default.
• W4211137142 cites W2143298757 @default.
• W4211137142 cites W2236627376 @default.
• W4211137142 cites W2529959700 @default.
• W4211137142 cites W2604242669 @default.
• W4211137142 cites W2747702054 @default.
• W4211137142 cites W2790092507 @default.
• W4211137142 cites W2790157546 @default.
• W4211137142 cites W2800954148 @default.
• W4211137142 cites W3173228391 @default.
• W4211137142 cites W3190148798 @default.
• W4211137142 cites W4243514703 @default.
• W4211137142 doi "https://doi.org/10.1080/10717544.2022.2032877" @default.
• W4211137142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35147054" @default.
• W4211137142 hasPublicationYear "2022" @default.
• W4211137142 type Work @default.
• W4211137142 citedByCount "0" @default.
• W4211137142 crossrefType "journal-article" @default.
• W4211137142 hasAuthorship W4211137142A5011241874 @default.
• W4211137142 hasAuthorship W4211137142A5011584029 @default.
• W4211137142 hasAuthorship W4211137142A5012313693 @default.
• W4211137142 hasAuthorship W4211137142A5033638005 @default.
• W4211137142 hasAuthorship W4211137142A5033785543 @default.
• W4211137142 hasAuthorship W4211137142A5056876818 @default.
• W4211137142 hasAuthorship W4211137142A5076606717 @default.
• W4211137142 hasBestOaLocation W42111371421 @default.
• W4211137142 hasConcept C112887158 @default.
• W4211137142 hasConcept C113196181 @default.
• W4211137142 hasConcept C127413603 @default.
• W4211137142 hasConcept C145148216 @default.
• W4211137142 hasConcept C160892712 @default.
• W4211137142 hasConcept C178790620 @default.
• W4211137142 hasConcept C185592680 @default.
• W4211137142 hasConcept C192562407 @default.
• W4211137142 hasConcept C202751555 @default.
• W4211137142 hasConcept C2775897365 @default.
• W4211137142 hasConcept C32909587 @default.
• W4211137142 hasConcept C34814092 @default.
• W4211137142 hasConcept C41625074 @default.
• W4211137142 hasConcept C42360764 @default.
• W4211137142 hasConcept C42475967 @default.
• W4211137142 hasConcept C50670333 @default.
• W4211137142 hasConcept C55493867 @default.
• W4211137142 hasConcept C80107235 @default.
• W4211137142 hasConceptScore W4211137142C112887158 @default.
• W4211137142 hasConceptScore W4211137142C113196181 @default.
• W4211137142 hasConceptScore W4211137142C127413603 @default.
• W4211137142 hasConceptScore W4211137142C145148216 @default.
• W4211137142 hasConceptScore W4211137142C160892712 @default.
• W4211137142 hasConceptScore W4211137142C178790620 @default.
• W4211137142 hasConceptScore W4211137142C185592680 @default.
• W4211137142 hasConceptScore W4211137142C192562407 @default.
• W4211137142 hasConceptScore W4211137142C202751555 @default.
• W4211137142 hasConceptScore W4211137142C2775897365 @default.
• W4211137142 hasConceptScore W4211137142C32909587 @default.
• W4211137142 hasConceptScore W4211137142C34814092 @default.
• W4211137142 hasConceptScore W4211137142C41625074 @default.
• W4211137142 hasConceptScore W4211137142C42360764 @default.
• W4211137142 hasConceptScore W4211137142C42475967 @default.
• W4211137142 hasConceptScore W4211137142C50670333 @default.
• W4211137142 hasConceptScore W4211137142C55493867 @default.
• W4211137142 hasConceptScore W4211137142C80107235 @default.
• W4211137142 hasFunder F4320322843 @default.
• W4211137142 hasIssue "1" @default.
• W4211137142 hasLocation W42111371421 @default.
• W4211137142 hasLocation W42111371422 @default.
• W4211137142 hasLocation W42111371423 @default.
• W4211137142 hasLocation W42111371424 @default.
• W4211137142 hasOpenAccess W4211137142 @default.
• W4211137142 hasPrimaryLocation W42111371421 @default.

• next